Protein Info for HEPCGN_06130 in Escherichia coli ECOR38

Annotation: Putative voltage-gated ClC-type chloride channel ClcB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 141 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 54 to 71 (18 residues), see Phobius details amino acids 97 to 116 (20 residues), see Phobius details amino acids 121 to 139 (19 residues), see Phobius details PF00654: Voltage_CLC" amino acids 60 to 137 (78 residues), 35.2 bits, see alignment E=4.2e-13

Best Hits

Predicted SEED Role

"FIG00509904: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (141 amino acids)

>HEPCGN_06130 Putative voltage-gated ClC-type chloride channel ClcB (Escherichia coli ECOR38)
MFRRLLIATVVGILAAFAVAGFRHAMLLLEWLFLNNDSGSLVNAATNLSPWRRLLTPALG
GLAAGLLLMGWQKFTQQRPHAPTDYMEALQTDGQFDYAASLVKSLASLLVVTSGSAIGRE
GAMILLAALAASCFAQRFTPR