Protein Info for HEPCGN_03660 in Escherichia coli ECOR38

Annotation: transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 135 PF13560: HTH_31" amino acids 6 to 61 (56 residues), 29.2 bits, see alignment E=9.5e-11 PF01381: HTH_3" amino acids 12 to 64 (53 residues), 53.3 bits, see alignment E=2.4e-18

Best Hits

Swiss-Prot: 57% identical to DICA_ECOLI: HTH-type transcriptional regulator DicA (dicA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 99% identity to ebr:ECB_01539)

Predicted SEED Role

"Similar to DicA, regulator of DicB encoded by prophage CP-933O"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (135 amino acids)

>HEPCGN_03660 transcriptional regulator (Escherichia coli ECOR38)
MDTRTLGQRVLARRKELRLTQREAARLAGVAHVTISQWERDETQPVGKRLFALADALKCS
PTWLMFGDEDKAPVPAQELHVETELTPSHKELIELFDALPSSEQEALLSEMRARVENFNK
LFEEMLKARKNKSIK