Protein Info for HEPCGN_03130 in Escherichia coli ECOR38

Name: vioA
Annotation: dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase VioA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 370 PF01041: DegT_DnrJ_EryC1" amino acids 18 to 363 (346 residues), 336.7 bits, see alignment E=1.9e-104 PF00155: Aminotran_1_2" amino acids 38 to 163 (126 residues), 25.9 bits, see alignment E=5.6e-10

Best Hits

Swiss-Prot: 60% identical to VIOA_SHIDY: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase (vioA) from Shigella dysenteriae

KEGG orthology group: None (inferred from 100% identity to ebd:ECBD_1619)

Predicted SEED Role

"Aminotransferase, DegT/DnrJ/EryC1/StrS family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (370 amino acids)

>HEPCGN_03130 dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase VioA (Escherichia coli ECOR38)
MNDKTIPVTQPSLPELAEFMPYLEKIWKNKWLTNNGPFHQELEEKLCEFLGVQHISLFNN
ATIALITALQALRITGEVITTPYSFVATSHAILWNGLTPVFVDIENDGYNIDYRKIEQAI
TPKTSAILPVHCYSTPCEVEEIQKIADNYGLKVIYDAAHAFGVNFKGQSLLNYGDLSILS
FHATKVFNTFEGGAIISPDAKTKLRIDRLKNFGIADELTVTAPGINGKMSEINAAFGLVQ
LKHIEGSISKRKIIDSLYRNLLKGTPGITIFPGNINTNSNYSYFPILIDDGFHMSRDQAY
ELLKKNNILSRKYFYPLISNMPMYRGLISASVDNLPIANSVADKVLCLPIYTDLNEEIVV
KITKLLLGKM