Protein Info for HEPCGN_02855 in Escherichia coli ECOR38

Annotation: type II toxin-antitoxin system ParD family antitoxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 83 PF03693: ParD_antitoxin" amino acids 1 to 77 (77 residues), 71.8 bits, see alignment E=2.6e-24 TIGR02606: putative addiction module antidote protein, CC2985 family" amino acids 4 to 74 (71 residues), 88.1 bits, see alignment E=1.6e-29

Best Hits

Swiss-Prot: 43% identical to PARD_VIBCH: Antitoxin ParD (parD) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K07746, hypothetical protein (inferred from 100% identity to efe:EFER_2169)

Predicted SEED Role

"putative transcriptional regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (83 amino acids)

>HEPCGN_02855 type II toxin-antitoxin system ParD family antitoxin (Escherichia coli ECOR38)
MARTMTVDLGDELREFIESLIESGDYRTQSEVIRESLRLLREKQAESRLQALRDMLAEGL
SSGEAQPWEKDAFLRKVKAGIRK