Protein Info for HEPCGN_02435 in Escherichia coli ECOR38

Name: tolA
Annotation: cell envelope integrity protein TolA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 142 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR02794: protein TolA" amino acids 47 to 142 (96 residues), 74 bits, see alignment E=6.6e-25 PF06519: TolA" amino acids 50 to 140 (91 residues), 84.1 bits, see alignment E=3.3e-28

Best Hits

KEGG orthology group: None (inferred from 68% identity to eck:EC55989_1719)

Predicted SEED Role

"TolA protein" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (142 amino acids)

>HEPCGN_02435 cell envelope integrity protein TolA (Escherichia coli ECOR38)
MYCRAVPVLVLILASLTTGCTKDVSTNNYDASLYHSDKLIKSQNLSSSERTPDASEEIRQ
YAIQVRKAIEEQLKDASKYSGKECSLRMYMAPNGLLLQVKREGGDPDLCREAMNAVKHAD
IPVPPSPEVYKVFHNGVLDFKP