Protein Info for HEPCGN_01635 in Escherichia coli ECOR38

Name: bioA
Annotation: adenosylmethionine--8-amino-7-oxononanoate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 TIGR00508: adenosylmethionine-8-amino-7-oxononanoate transaminase" amino acids 13 to 421 (409 residues), 610.1 bits, see alignment E=8.1e-188 PF00202: Aminotran_3" amino acids 26 to 420 (395 residues), 433.3 bits, see alignment E=3.9e-134

Best Hits

Swiss-Prot: 99% identical to BIOA_ECOLI: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA) from Escherichia coli (strain K12)

KEGG orthology group: K00833, adenosylmethionine-8-amino-7-oxononanoate aminotransferase [EC: 2.6.1.62] (inferred from 99% identity to eco:b0774)

MetaCyc: 99% identical to adenosylmethionine-8-amino-7-oxononanoate aminotransferase (Escherichia coli K-12 substr. MG1655)
Adenosylmethionine--8-amino-7-oxononanoate transaminase. [EC: 2.6.1.62]

Predicted SEED Role

"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.62

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (429 amino acids)

>HEPCGN_01635 adenosylmethionine--8-amino-7-oxononanoate transaminase (Escherichia coli ECOR38)
MTTDDLAFDQRHIWHPYTSMTSPLPVYPVASAEGCELILSDGRRLVDGMSSWWAAIHGYN
HPQLNAAMKSQIDAMSHVMFGGITHAPAIELCRKLVAMTPQPLECVFLADSGSVAVEVAM
KMALQYWQAKGEARQRFLTFRNGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQS
RLDGEWDERDMVGFARLMAAHRHEIAAVIIEPIVQGAGGMRMYHPEWLKRIRKMCDREGI
LLIADEIATGFGRTGKLFACEHAEIAPDILCLGKALTGGTMTLSATLTTREVAETISNGE
AGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVAAIEVQLREQLAPACDAEMVADVR
VLGAIGVVETTRPVNMAALQKFFVEQGVWIRPFGKLIYLMPPYIILPQQLQRLTAAVNRA
VQDETFFCQ