Protein Info for HEPCGN_01380 in Escherichia coli ECOR38

Name: gltP
Annotation: dicarboxylate/amino acid:cation symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 43 to 67 (25 residues), see Phobius details amino acids 83 to 105 (23 residues), see Phobius details amino acids 152 to 170 (19 residues), see Phobius details amino acids 190 to 211 (22 residues), see Phobius details amino acids 223 to 248 (26 residues), see Phobius details amino acids 294 to 318 (25 residues), see Phobius details amino acids 324 to 341 (18 residues), see Phobius details amino acids 354 to 374 (21 residues), see Phobius details PF00375: SDF" amino acids 6 to 402 (397 residues), 343.4 bits, see alignment E=9e-107

Best Hits

Swiss-Prot: 38% identical to DCTA_LARHH: C4-dicarboxylate transport protein (dctA) from Laribacter hongkongensis (strain HLHK9)

KEGG orthology group: None (inferred from 99% identity to eum:ECUMN_0811)

MetaCyc: 37% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"Putative symport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (426 amino acids)

>HEPCGN_01380 dicarboxylate/amino acid:cation symporter (Escherichia coli ECOR38)
MKKISLTTMILLALVLGMIIGVVLNNTASPETAKLYAQEISIFTTIFLRLIKMIIAPLVV
STLVVGIAKMGDAKALGRIFSKTLFLFICASLLSIALGLITVNFFMPGTGINFVAHGAET
TGVVASEPFTLKVFISHAFPTSIVDAMAHNEILQIVVFSIFLGCSLTAIGEKGSAIVHAL
DSLAHAMLKLTGYVMLFAPLTVFAAISTLIAERGLAVMVSAGIFMGEFYFTMLLLWVLLI
GLAIVYVGPCIRRLPRALSEPALLAFTTSSSEAAFPGTLEKLEQFGVSPKIASFVLPIGY
SFNLVGSMAYCSFATVFIAQACNIHLSIGEQITMLLILMLTSKGMAGVPRASMVVIAATL
NQFNIPEAGLILLMGVDPFLDMGRSATNVMSNAMGAAMVSRWEGEHFGEGCRGKALKPNE
SNVALP