Protein Info for HEPCGN_01170 in Escherichia coli ECOR38

Name: kdpB
Annotation: potassium-transporting ATPase subunit KdpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 682 transmembrane" amino acids 35 to 56 (22 residues), see Phobius details amino acids 62 to 82 (21 residues), see Phobius details amino acids 219 to 242 (24 residues), see Phobius details amino acids 252 to 276 (25 residues), see Phobius details amino acids 580 to 596 (17 residues), see Phobius details amino acids 616 to 636 (21 residues), see Phobius details amino acids 654 to 677 (24 residues), see Phobius details TIGR01497: K+-transporting ATPase, B subunit" amino acids 2 to 677 (676 residues), 1281.1 bits, see alignment E=0 TIGR01494: HAD ATPase, P-type, family IC" amino acids 72 to 337 (266 residues), 127.8 bits, see alignment E=4e-41 amino acids 372 to 604 (233 residues), 166 bits, see alignment E=1.1e-52 PF00122: E1-E2_ATPase" amino acids 119 to 282 (164 residues), 111.3 bits, see alignment E=6e-36 PF00702: Hydrolase" amino acids 301 to 530 (230 residues), 103.9 bits, see alignment E=2.3e-33

Best Hits

Swiss-Prot: 100% identical to KDPB_ECO7I: Potassium-transporting ATPase ATP-binding subunit (kdpB) from Escherichia coli O7:K1 (strain IAI39 / ExPEC)

KEGG orthology group: K01547, K+-transporting ATPase ATPase B chain [EC: 3.6.3.12] (inferred from 100% identity to ecs:ECs0725)

MetaCyc: 100% identical to K+ transporting P-type ATPase subunit KdpB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-2 [EC: 7.2.2.6]

Predicted SEED Role

"Potassium-transporting ATPase B chain (EC 3.6.3.12) (TC 3.A.3.7.1)" in subsystem Potassium homeostasis (EC 3.6.3.12, TC 3.A.3.7.1)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.12

Use Curated BLAST to search for 3.6.3.12 or 7.2.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (682 amino acids)

>HEPCGN_01170 potassium-transporting ATPase subunit KdpB (Escherichia coli ECOR38)
MSRKQLALFEPTLVVQALKEAVKKLNPQAQWRNPVMFIVWIGSLLTTCISIAMASGAMPG
NALFSAAISGWLWVTVLFANFAEALAEGRSKAQANSLKGVKKTAFARKLREPKYGAAADK
VPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGT
RILSDWLVIECSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLW
PFSAWGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGD
VDVLLLDKTGTITLGNRQASEFIPAQGVDEKTLADAAQLASLADETPEGRSIVILAKQRF
NLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVEANGGHFPADVDQKV
DQVARQGATPLVVVEGSRVLGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAA
IAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQ
AAKEAGNMVDLDSNPTKLIEVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYP
QLNALNIMRLHSPDSAILSAVIFNALIIVFLIPLALKGVSYKPLTASAMLRRNLWIYGLG
GLLVPFIGIKVIDLLLTVCGLV