Protein Info for HEPCGN_00805 in Escherichia coli ECOR38

Name: citG
Annotation: triphosphoribosyl-dephospho-CoA synthase CitG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 TIGR03125: triphosphoribosyl-dephospho-CoA synthase CitG" amino acids 21 to 291 (271 residues), 361.4 bits, see alignment E=1.7e-112 PF01874: CitG" amino acids 26 to 290 (265 residues), 271.5 bits, see alignment E=4.9e-85

Best Hits

Swiss-Prot: 100% identical to CITG_ECO7I: 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (citG) from Escherichia coli O7:K1 (strain IAI39 / ExPEC)

KEGG orthology group: K05966, triphosphoribosyl-dephospho-CoA synthase [EC: 2.7.8.25] (inferred from 99% identity to ecm:EcSMS35_0632)

MetaCyc: 98% identical to triphosphoribosyl-dephospho-CoA synthase (Escherichia coli K-12 substr. MG1655)
2.7.8.25-RXN [EC: 2.4.2.52]

Predicted SEED Role

"2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC 2.7.8.25)" (EC 2.7.8.25)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.52 or 2.7.8.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (292 amino acids)

>HEPCGN_00805 triphosphoribosyl-dephospho-CoA synthase CitG (Escherichia coli ECOR38)
MSMPATSTKTTKLATSLIDEYALLGWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHR
SALAIQGWLPRFIEFGACSAEMAPEAVLNGLRPIGMACEGDMFRATAGVNTHKGSIFSLG
LLCAAIGRLLQLNQPVTPTTVCSTAASFCRGLTDRELRTNNSQRTAGQRLYQQLGLTGAR
GEAEAGYPLVINHALPHYLTLLDQGLDPELALLDTLLLLMATNGDTNVASRGGEGGLRWL
QREAQTLLNNGGIRTPADLDYLRQFDRECIERNLSPGGSADLLILTWFLAQI