Protein Info for GFF966 in Variovorax sp. SCN45

Annotation: Probable two-component transmembrane sensor histidine kinase transcription regulator protein (EC 2.7.3.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 846 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details transmembrane" amino acids 40 to 60 (21 residues), see Phobius details amino acids 290 to 313 (24 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 331 to 454 (124 residues), 91.4 bits, see alignment E=2.4e-30 PF13188: PAS_8" amino acids 332 to 386 (55 residues), 32.8 bits, see alignment 1.7e-11 PF00989: PAS" amino acids 332 to 444 (113 residues), 67.3 bits, see alignment E=4.2e-22 PF08448: PAS_4" amino acids 345 to 447 (103 residues), 37.2 bits, see alignment E=1.1e-12 PF13426: PAS_9" amino acids 346 to 446 (101 residues), 48.3 bits, see alignment E=3.8e-16 PF08447: PAS_3" amino acids 354 to 437 (84 residues), 26.5 bits, see alignment E=2.2e-09 PF00512: HisKA" amino acids 601 to 668 (68 residues), 34.5 bits, see alignment E=6.2e-12 PF02518: HATPase_c" amino acids 713 to 830 (118 residues), 61 bits, see alignment E=5e-20

Best Hits

KEGG orthology group: None (inferred from 98% identity to vpe:Varpa_3731)

Predicted SEED Role

"Probable two-component transmembrane sensor histidine kinase transcription regulator protein (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (846 amino acids)

>GFF966 Probable two-component transmembrane sensor histidine kinase transcription regulator protein (EC 2.7.3.-) (Variovorax sp. SCN45)
MPLSSPLAVARSAVNASPLSWWRRWWRKQTPVLQDAVAMLAPMAAVLLFLAAIVSAFWYL
RTEEVEREQESVRRDVEYAQQRMRLRLLERQEQLMRIARDASNREIDPIEFTSRAESLVS
QFPELQTITWIDDRRRFKAGYAAPSVHPAQQHLIGDVLRPGDIESNYALARELRQPVYSQ
PAAGGDPPAMLQLHIPLFDQGLFAGVVLGEFSVDGLLRYGMPSEVQARYAVSLLDAKGHV
IAGNTTNLKDSGTRLLPWTERTNEYEVPVSPVGNALVLRAQAYRTSQGVVGNGLFWLVCA
LSVLTSWMLIGTWRHTRRRLQAQQRLVAETNFRRAMENSMLTGMRVLDLQGRITYVNAAF
CAMTGWSEEELVGQSPPFPYWLESDREVMNERLEEELHGRALPGGFQVRVKRKNGSVFNA
RLYVSPLIDARGHQTGWMTSMTDITEPTRIREQLSASYERFTTVLEALDAAVSVAPIGSE
ELLFANKLYRLWFGSDTVGHLGMVAQAGVPASNAHDEGLDDVDPYAGLPIDTLTAAQTAN
NEIFVPHLGKWLEVRSRYLTWVDGRLAQLVIATDITPRRDAEEQAAAQADKAQAASRLIT
MGEMASSVAHELNQPLTAITNYCNGMMSRIKGQTIDTEALLAALEKTSKQAQRAGQIIQR
IRSFVKRSEPNRTPADVATMVSEAVELAGIELRRRNVRLNHYVAARLPVVRVDPILIEQV
MVNLLKNAAESIDIADRPLARRSVELRVLPKVIEGHNAIEFSVQDTGKGLAPEVMDRLYE
AFFSTKPEGMGIGLNLCRTIVESHRGRMQAENIYNGPDVIGCRFSFWIPVLDAISSVASD
EAKVPA