Protein Info for GFF953 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: L-idonate, D-gluconate, 5-keto-D-gluconate transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 signal peptide" amino acids 9 to 11 (3 residues), see Phobius details transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 54 to 75 (22 residues), see Phobius details amino acids 98 to 129 (32 residues), see Phobius details amino acids 135 to 154 (20 residues), see Phobius details amino acids 175 to 194 (20 residues), see Phobius details amino acids 222 to 242 (21 residues), see Phobius details amino acids 254 to 276 (23 residues), see Phobius details amino acids 295 to 313 (19 residues), see Phobius details amino acids 324 to 345 (22 residues), see Phobius details amino acids 350 to 369 (20 residues), see Phobius details amino acids 377 to 393 (17 residues), see Phobius details amino acids 415 to 438 (24 residues), see Phobius details TIGR00791: transporter, gluconate:H+ symporter (GntP) family" amino acids 1 to 438 (438 residues), 660.3 bits, see alignment E=7.5e-203 PF02447: GntP_permease" amino acids 1 to 436 (436 residues), 613.7 bits, see alignment E=2.8e-188 PF03600: CitMHS" amino acids 22 to 384 (363 residues), 52.3 bits, see alignment E=7.3e-18 PF06808: DctM" amino acids 198 to 378 (181 residues), 24.5 bits, see alignment E=1.8e-09

Best Hits

Swiss-Prot: 94% identical to IDNT_ECOLI: Gnt-II system L-idonate transporter (idnT) from Escherichia coli (strain K12)

KEGG orthology group: K06157, Gnt-II system L-idonate transporter (inferred from 100% identity to sew:SeSA_A4737)

MetaCyc: 94% identical to L-idonate/5-ketogluconate/gluconate transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-181A; TRANS-RXN0-209; TRANS-RXN0-228

Predicted SEED Role

"L-idonate, D-gluconate, 5-keto-D-gluconate transporter" in subsystem D-gluconate and ketogluconates metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (439 amino acids)

>GFF953 L-idonate, D-gluconate, 5-keto-D-gluconate transporter (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MPLIIIAAGVALLLVLMIGFKVNGFIALVLVAAVVGFAEGMGAQDVLHSIQNGIGGTLGG
LAMILGFGAMLGRLISDTGAAQRIATTLINTFGKKRVQWALVITGLIVGLAMFFEVGFVL
LLPLVFTIVASSGLPLLYVGVPMVAALSVTHCFLPPHPGPTAIATIFEANLGTTLLYGLI
ITIPTVIVAGPLFSKLLARFEKAPPEGLFNPHLFSEEEMPSFWNSIFAAVIPVILMAIAA
VCEITLPKTNAVRVFFEFIGNPAVALFIAIIIAIFTLGRRNGRTVEQVMDIVGESIGAIA
MIVFIIAGGGAFKQVLVDSGVGQYISQLMTGTSLSPLLMCWTVAAVLRIALGSATVAAIT
TAGVVLPIINVTHADPALMVLATGAGSVIASHVNDPGFWLFKGYFNLSVGETLRTWTVME
TLISVMGLLGVLALNAVLH