Protein Info for GFF950 in Variovorax sp. SCN45

Annotation: Chaperone protein HscB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 172 TIGR00714: Fe-S protein assembly co-chaperone HscB" amino acids 19 to 166 (148 residues), 99.8 bits, see alignment E=8.2e-33 PF07743: HSCB_C" amino acids 91 to 163 (73 residues), 70.5 bits, see alignment E=6.3e-24

Best Hits

Swiss-Prot: 49% identical to HSCB_BORPA: Co-chaperone protein HscB homolog (hscB) from Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

KEGG orthology group: K04082, molecular chaperone HscB (inferred from 92% identity to vap:Vapar_2145)

Predicted SEED Role

"Chaperone protein HscB" in subsystem Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (172 amino acids)

>GFF950 Chaperone protein HscB (Variovorax sp. SCN45)
MNLNDTDFELFAVPATFAQDRAALDARWKELQREAHPDRFAAQGAAAQRVAMQWSVRINE
AYQRLKDPIRRASYICEMNGAPLNAENNTAMPPEFLMQQMEWREALDDVENVESLEKLQA
EVEAGRARALSSLDWLIDEKGDYPAAAQQVRALMFIERFGQDVEAKFDQLGQ