Protein Info for GFF921 in Variovorax sp. SCN45

Annotation: Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00700: 4-aminobutyrate transaminase
  • amino acids 14 to 423 (410 residues), 576.2 bits, E=1.6e-177
• PF00202: Aminotran_3
  • amino acids 28 to 422 (395 residues), 417.4 bits, E=5.3e-129

Best Hits

Swiss-Prot: 55% identical to PUUE_ECOLI: 4-aminobutyrate aminotransferase PuuE (puuE) from Escherichia coli (strain K12)

KEGG orthology group: K00823, 4-aminobutyrate aminotransferase [EC: 2.6.1.19] (inferred from 65% identity to bam:Bamb_4711)

MetaCyc: 59% identical to 4-aminobutyrate aminotransferase monomer (Cupriavidus necator H16)
4-aminobutyrate transaminase. [EC: 2.6.1.19]; 2.6.1.- [EC: 2.6.1.19]

Predicted SEED Role

"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)

MetaCyc Pathways

• superpathway of 4-aminobutanoate degradation (3/3 steps found)
• 4-aminobutanoate degradation I (2/2 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (3/4 steps found)
• 4-aminobutanoate degradation V (5/7 steps found)
• homotaurine degradation (1/2 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• nicotine degradation I (pyridine pathway) (5/17 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Butanoate metabolism
• Glutamate metabolism
• Propanoate metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.19

Protein Sequence (429 amino acids)

>GFF921 Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19) (Variovorax sp. SCN45)
MLTQVTTNASLQARKNAACAQGVGTLTPHFVSRAGNAELWDVEGRRFVDFASGIATLATG
HRHPRIVEAVRAQLDDFHHTCFHVTPYEEYVALCEQLNRLVPGDFAKKSALFTTGAEAVE
NAMKVARVATGRSGVVAFSGAFHGRTFMGMALTGKVAPYKAGFGPMPADVWHVPFPAAPL
GVTVEDSIAALDRLFRTDVDPRRVAAIVIELVQGEGGFYVAPPKLLEHLRAVCDQHGILL
VCDEIQTGFGRTGKLFALEHYGVEADLVTMAKSLAGGFPLSALTGRAEVMDAALVGSIGG
TYAGNPLAVAAALETIRVIGDEKLVERASMLGERLAAQLRSLQAQEPRICDVRGLGAMVA
VEFRDPRTGEPDADFTRRVHAAGLQRGLLLLTCGVHGNVVRFLFALTIPDDVFEEGLSLL
AGAVLDAAR