Protein Info for GFF912 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Butyryl-CoA dehydrogenase (EC 1.3.99.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 389 PF02771: Acyl-CoA_dh_N" amino acids 12 to 122 (111 residues), 102.5 bits, see alignment E=3.8e-33 PF02770: Acyl-CoA_dh_M" amino acids 126 to 221 (96 residues), 84 bits, see alignment E=1.4e-27 PF00441: Acyl-CoA_dh_1" amino acids 235 to 383 (149 residues), 172.4 bits, see alignment E=1.4e-54 PF08028: Acyl-CoA_dh_2" amino acids 252 to 367 (116 residues), 80 bits, see alignment E=3.9e-26

Best Hits

Swiss-Prot: 40% identical to ACRC_CLOPR: Acryloyl-CoA reductase (NADH) (acrC) from Clostridium propionicum

KEGG orthology group: None (inferred from 72% identity to bpt:Bpet0851)

MetaCyc: 40% identical to propionyl-CoA dehydrogenase (Anaerotignum propionicum)

Predicted SEED Role

"Butyryl-CoA dehydrogenase (EC 1.3.99.2)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases or Butanol Biosynthesis or Isobutyryl-CoA to Propionyl-CoA Module or Isoleucine degradation or Valine degradation (EC 1.3.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.2

Use Curated BLAST to search for 1.3.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (389 amino acids)

>GFF912 Butyryl-CoA dehydrogenase (EC 1.3.99.2) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTTSPPIAFDAEKETLVLDAVERFVDREIKPVAQRLEHADEWPADIVAGMREMGLFGCII
REEYGGLGLSASTYAKVVERIARVWMSVSGIINSHLIMAACVQRNGTEAQRQCFLPRFAS
GELRGGLALTEPDCGTDLQAVRTVARRDGDHYVINGTKTWISNGVHGQAFAVLVKTDPAA
QPRHRGMSLFICEKGPGFTSTRKLEKLGYKGIDSAELVFDNFRVSAANLVGGVEGQGFKH
VMGGLELGRINVAARGVGVARACLEESVAYAQLRRTFGKPICEHQAIQLKLADMATRAEA
ARLLVEQAARAYDAGQRCDMEAGMAKLFASEAAVENSMEALRIHGAYGYSKEMNVERYYR
DAPLLCIGEGTNELQRLIISAQLVERSPI