Protein Info for GFF869 in Variovorax sp. SCN45

Annotation: Transcriptional regulator RutR of pyrimidine catabolism (TetR family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 217 PF00440: TetR_N" amino acids 28 to 73 (46 residues), 42.7 bits, see alignment 3.9e-15 PF08362: TetR_C_3" amino acids 78 to 216 (139 residues), 128.7 bits, see alignment E=1.7e-41

Best Hits

KEGG orthology group: K09017, TetR/AcrR family transcriptional regulator (inferred from 39% identity to bbt:BBta_6034)

Predicted SEED Role

"Transcriptional regulator RutR of pyrimidine catabolism (TetR family)" in subsystem Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (217 amino acids)

>GFF869 Transcriptional regulator RutR of pyrimidine catabolism (TetR family) (Variovorax sp. SCN45)
MRDTKTTRPPAPETTADREIRAANKRKILKAASEVFAAKGFDGARIAEIASVAELPKANV
YYYYATKEDLYSATFAPLLEEWDSALRILKVETEPAVALRAYVEAKLRLGRKNPLEARLF
ANEVVRGGTFLSAADRAHIAQSTAASIEVLEAWMAAKKIRKIDARHFLFMLWASTQFYAD
YEPIVNAVLQVKKLTAVHYEQALECIVSTVLAGVLLD