Protein Info for GFF861 in Variovorax sp. SCN45

Annotation: S-adenosylhomocysteine deaminase (EC 3.5.4.28); Methylthioadenosine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 PF01979: Amidohydro_1" amino acids 61 to 442 (382 residues), 191.5 bits, see alignment E=2.5e-60 PF07969: Amidohydro_3" amino acids 182 to 442 (261 residues), 59 bits, see alignment E=6.3e-20

Best Hits

KEGG orthology group: None (inferred from 49% identity to sno:Snov_3610)

Predicted SEED Role

"S-adenosylhomocysteine deaminase (EC 3.5.4.28); Methylthioadenosine deaminase" (EC 3.5.4.28)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.28

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (507 amino acids)

>GFF861 S-adenosylhomocysteine deaminase (EC 3.5.4.28); Methylthioadenosine deaminase (Variovorax sp. SCN45)
MTTTPALTLIRGAEVLTMAGPQGTQPVHADLLLRDGRIEAIGPGLPVPPVCTLVEAHGKL
LMPGLVNAHTHSSETFFKGRYEGMPLETWLLYAYTYLGGGPIPDRLLYLRTLLLAMQSLK
SGVTTLCDDFFDPMAHGIDRLGIVFQAYRDAGIRVNVSSAVLNTPVLDSTPFGHELFPEH
LSAQLKFGAPTTAADYTAYCEEAFRQFHGQADGRLRFAITPSAPQRCTVDMLQACHALAV
RHGVPLHTHLLETKVQAVAGQMFYGKTLVAHMHDIGILDRHATLAHAIWLTDADVARMGE
AGCTVVHNPLSNLKLGSGLSPIRKLLDAGVRIGLGTDGLSSNDSARVFDLMRFAALMHNG
PASDAAEWPVAAEVLKMATIDGARTALLDDTTGSLEVGKAADLLMLGMDNDNFRPRNDIA
RQLVYCENGSSVELVMVGGRVVSQGGRLHTVDETAVWAELDELLPAYLREHGKWEAANQV
FEPCFAEVIRRCKAVDLPGLPRFTPAA