Protein Info for GFF847 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Ascorbate-specific PTS system, EIIC component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 transmembrane" amino acids 14 to 34 (21 residues), see Phobius details amino acids 46 to 66 (21 residues), see Phobius details amino acids 100 to 121 (22 residues), see Phobius details amino acids 133 to 151 (19 residues), see Phobius details amino acids 153 to 172 (20 residues), see Phobius details amino acids 232 to 253 (22 residues), see Phobius details amino acids 265 to 285 (21 residues), see Phobius details amino acids 305 to 331 (27 residues), see Phobius details amino acids 335 to 362 (28 residues), see Phobius details amino acids 379 to 402 (24 residues), see Phobius details amino acids 422 to 445 (24 residues), see Phobius details PF03611: EIIC-GAT" amino acids 15 to 406 (392 residues), 371.9 bits, see alignment E=2.1e-115

Best Hits

Swiss-Prot: 100% identical to ULAA_SALTY: Ascorbate-specific PTS system EIIC component (ulaA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03475, PTS system, ascorbate-specific IIC component (inferred from 99% identity to spt:SPA4200)

MetaCyc: 98% identical to L-ascorbate specific PTS enzyme IIC component (Escherichia coli K-12 substr. MG1655)
RXN0-2461 [EC: 2.7.1.194]

Predicted SEED Role

"Ascorbate-specific PTS system, EIIC component" in subsystem L-ascorbate utilization (and related gene clusters)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.194

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (465 amino acids)

>GFF847 Ascorbate-specific PTS system, EIIC component (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MEILYNIFTIFFNQVMTNAPLLLGIVTCLGYILLRKSVSVIIKGTIKTIIGFMLLQAGSG
ILTSTFKPVVAKMSEVYGINGAISDTYASMMATIERMGDAYSWVGYAVLLALALNICYVL
LRRITGIRTIMLTGHIMFQQAGLIAVSFYIFGYSMWTTIICTAILVSLYWGITSNMMYKP
TQEVTDGCGFSIGHQQQFASWIAYKVAPFLGKKEESVEDLKLPGWLNIFHDNIVSTAIVM
TIFFGAILLSFGIDTVQAMAGKTHWTIYILQTGFSFAVAIFIITQGVRMFVAELSEAFNG
ISQRLIPGAVLAIDCAAIYSFAPNAVVWGFMWGTIGQLIAVGILVACGSSILIIPGFIPM
FFSNATIGVFANHFGGWRAALKICLVMGMIEIFGCVWAVKLTGMSAWMGMADWSILAPPM
MQGFFSLGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA