Protein Info for GFF823 in Variovorax sp. SCN45

Annotation: Inner membrane protein YbaL, KefB/KefC family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 568 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 33 to 51 (19 residues), see Phobius details amino acids 57 to 77 (21 residues), see Phobius details amino acids 88 to 110 (23 residues), see Phobius details amino acids 116 to 136 (21 residues), see Phobius details amino acids 148 to 168 (21 residues), see Phobius details amino acids 188 to 209 (22 residues), see Phobius details amino acids 229 to 260 (32 residues), see Phobius details amino acids 280 to 301 (22 residues), see Phobius details amino acids 308 to 331 (24 residues), see Phobius details amino acids 343 to 364 (22 residues), see Phobius details amino acids 371 to 391 (21 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 17 to 387 (371 residues), 178 bits, see alignment E=2.8e-56 PF02254: TrkA_N" amino acids 430 to 543 (114 residues), 90.8 bits, see alignment E=8e-30

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 95% identity to vpe:Varpa_3854)

Predicted SEED Role

"TrkA-N:Sodium/hydrogen exchanger" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (568 amino acids)

>GFF823 Inner membrane protein YbaL, KefB/KefC family (Variovorax sp. SCN45)
MPHSVSLINTIAAGLGLALVFGFLAAKLRLPALVGYLLAGVIIGPFTPGFVADAGIAAQL
AEIGVMLLMFGVGLHFSLDDLLAVRKIALPGALAQIAVATLLGGGLAMWWGWSPGAALVF
GLALSVASTVVLLRALESLGILDSFTGRIAIGWLVVEDLAMVLVLVLMPPLAGTLGGHAA
QEGPADPLWQTLGLTLLQVGGFVALMLVVGRRVFPWILWQVTRTGSRELFTLCVVAAAVS
IAFASAALFGVSFALGAFFAGMVMRESQFAHRAAEESLPLRDAFAVLFFVSVGMLFDPSV
LIERPLQVLAVVLVIVLGKSLAACALVLVFRYPLGTALTVSASLAQIGEFSFILAGLGVS
LGLLPVEGQSLVLAGALISIATNPLWFSLIAPMQKWLHAHSSFARGLESRDDPLAELPMT
TEAKYLSRQVVLVGYGRVGRRIAAELDANDIPYVVAEQNRELVEKLREAGTPAVWGDAAD
PAVLIQAHVARARVLVVATPDAMNVRQMIETARTLNPTIQTVIRSHNEQEAKLLTQETAA
TVFLGEHELAQAMARDVVQRAVSMAAPA