Protein Info for GFF815 in Variovorax sp. SCN45

Annotation: COGs COG3777

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 305 PF13452: FAS1_DH_region" amino acids 96 to 160 (65 residues), 40 bits, see alignment E=2.1e-14

Best Hits

Swiss-Prot: 47% identical to MEH_CHLAA: Mesaconyl-C(4)-CoA hydratase (meh) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)

KEGG orthology group: K09709, mesaconyl-C4 CoA hydratase (inferred from 92% identity to vap:Vapar_2026)

MetaCyc: 47% identical to mesaconyl-C4-CoA hydratase monomer (Chloroflexus aurantiacus)
RXN-8965 [EC: 4.2.1.153]

Predicted SEED Role

"COGs COG3777"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.153

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (305 amino acids)

>GFF815 COGs COG3777 (Variovorax sp. SCN45)
LNDTKNPMSTDTPTTPSTIDSDALAKLQAWQGRSETLADDITAAPVRALSATLDRDDAAP
VAGTRLPELWHWLYFLPHHRQSEIGEDGHARRGGFLPPVPLPRRMWAGGRLRWEAGNPLR
VGDKVERTSTIASVTHKAGRTGELVFVLVRHEVRNERGLALTEEHDIVYRAAAQPGDAVP
PPTPAPKDAAFSRDIAPDDVLLFRYSALTFNGHRIHYDRRYVTQVEGYPGLIVHGPLIAT
LLVDLLRRNVPGAQLARFEFRAVRPTFDIAPFRVHGKPGADGKTFSLWGEDADGWLTMQA
TAVLA