Protein Info for GFF80 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: Ferric hydroxamate ABC transporter (TC 3.A.1.14.3), ATP-binding protein FhuC
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 92% identical to FHUC_ECOLI: Iron(3+)-hydroxamate import ATP-binding protein FhuC (fhuC) from Escherichia coli (strain K12)
KEGG orthology group: K02013, iron complex transport system ATP-binding protein [EC: 3.6.3.34] (inferred from 98% identity to ses:SARI_02805)MetaCyc: 92% identical to iron(III) hydroxamate ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
ABC-11-RXN [EC: 7.2.2.16]; TRANS-RXN-297 [EC: 7.2.2.16]; TRANS-RXN-298 [EC: 7.2.2.16]
Predicted SEED Role
"Ferric hydroxamate ABC transporter (TC 3.A.1.14.3), ATP-binding protein FhuC" in subsystem Iron acquisition in Vibrio or Siderophore Aerobactin (TC 3.A.1.14.3)
Isozymes
Compare fitness of predicted isozymes for: 3.6.3.34
Use Curated BLAST to search for 3.6.3.34 or 7.2.2.16
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (265 amino acids)
>GFF80 Ferric hydroxamate ABC transporter (TC 3.A.1.14.3), ATP-binding protein FhuC (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MQENHIHSDTTFALRSVAFRVPGRTLLHPLSLTFPAGRVTGLIGHNGSGKSTLLKMLGRH QPPSEGDILLDNQPLASWSSKAFARKVAYLPQQLPQAEGMTVRELVAIGRYPWHGALGRF GVADREKVDEAITLVGLKPLAHRLVDSLSGGERQRAWIAMLVAQDSRCLLLDEPTSALDI AHQVDVLALVHRLSQQRGLTVVAVLHDINMAARYCDYLVALRGGEMIAQGTPAELMRSDT LEQIYGIPMGILPHPAGAAPVSFVY