Protein Info for GFF77 in Methylophilus sp. DMC18

Annotation: Methylthioribose-1-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00512: S-methyl-5-thioribose-1-phosphate isomerase
  • amino acids 10 to 346 (337 residues), 409.7 bits, E=8.2e-127
• TIGR00524: eIF-2B alpha/beta/delta-related uncharacterized proteins
  • amino acids 38 to 347 (310 residues), 312.7 bits, E=2.3e-97
• PF01008: IF-2B
  • amino acids 49 to 347 (299 residues), 242.9 bits, E=2.1e-76

Best Hits

Swiss-Prot: 63% identical to MTNA_RHORT: Methylthioribose-1-phosphate isomerase (mtnA) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K08963, methylthioribose-1-phosphate isomerase [EC: 5.3.1.23] (inferred from 66% identity to meh:M301_1081)

MetaCyc: 63% identical to methylthioribose-1-phosphate isomerase (Rhodospirillum rubrum)
S-methyl-5-thioribose-1-phosphate isomerase. [EC: 5.3.1.23]; 5.3.1.23 [EC: 5.3.1.23]

Predicted SEED Role

"Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)" in subsystem Methionine Salvage (EC 5.3.1.23)

MetaCyc Pathways

• 5'-deoxyadenosine degradation I (3/3 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation III (3/5 steps found)
• 5'-deoxyadenosine degradation II (2/4 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation II (2/5 steps found)
• L-methionine salvage cycle III (4/11 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation I (1/7 steps found)
• L-methionine salvage cycle I (bacteria and plants) (3/12 steps found)
• L-methionine salvage cycle II (plants) (2/11 steps found)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.23

Protein Sequence (360 amino acids)

>GFF77 Methylthioribose-1-phosphate isomerase (Methylophilus sp. DMC18)
MRIQSQHFRSIWQQANAVYIIDQTQLPFDFVTVELTSLAQICHAIRHMQVRGAPLIGAAA
AYGVALGIQQDASDEHLQAVVKQLIATRPTAVNLAWAAQRMQQTLMPLAVAQRAAAAWLA
AQAIADEDVAQNLAIGQHGKALIAEKATVDANQAVNILTHCNAGWLATVDGGTALAPIYA
AHDAGLKVHVWVDETRPRNQGASLTAWELAQHGVPHTVIADNAGGHLMQHGQVDLVIVGA
DRVTSQGDVCNKIGTYLKALAALDQQIPFYAAVPTPTIDWQIARGAEIEIEMRDADEVAY
MQGQTATGDIETVRVIPHESPALNPAFDVTPARLVTGVITEHGVFAPDQLHALKTHILGN