Protein Info for GFF7303 in Variovorax sp. SCN45

Annotation: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 TIGR02091: glucose-1-phosphate adenylyltransferase" amino acids 24 to 406 (383 residues), 501 bits, see alignment E=9.7e-155 PF12804: NTP_transf_3" amino acids 26 to 154 (129 residues), 29.8 bits, see alignment E=6.6e-11 PF00483: NTP_transferase" amino acids 26 to 300 (275 residues), 216.9 bits, see alignment E=3.4e-68

Best Hits

Swiss-Prot: 70% identical to GLGC_PARPJ: Glucose-1-phosphate adenylyltransferase (glgC) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K00975, glucose-1-phosphate adenylyltransferase [EC: 2.7.7.27] (inferred from 90% identity to vpe:Varpa_0440)

MetaCyc: 65% identical to glucose-1-phosphate adenylyltransferase (Escherichia coli K-12 substr. MG1655)
Glucose-1-phosphate adenylyltransferase. [EC: 2.7.7.27]

Predicted SEED Role

"Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)" in subsystem Glycogen metabolism (EC 2.7.7.27)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.27

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>GFF7303 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (Variovorax sp. SCN45)
MDNLAPKAPQQQHELQAHQLVRRTIALVLAGGRGSRLKQLTDRRAKPAVYFGGKFRIIDF
ALSNCLNSGIRRMAVVTQYKSHSLMRHLQRGWSFLRAELNEMVDVLPAQQRVGDEHWYRG
TADAVFQNLDIIQTRSTPHDYVVVLAGDHIYKMDYSIMLKDHAEHGMGCTVGCIEVPRME
ATAFGVMHVDGDRKVTAFLEKPADPPAMPGKPDVALASMGIYVFDSDYLYRLLEEDSKDP
DSDHDFGKDIIPRAVAEGRALAHPFGMSCVTRAMRGGDSPTYWRDVGTIDAFWAANLDLA
SITPELDIYDTNWPIWTYQRQLPPAKFVFGRDGKPGLTTNTIVSGGCIVSGSSVSDSVLF
SGVRIHSFCTISQAVLLPDVEVGRGCRLSKVVIDRACVIPEDMVIGEDAEADAARFERTE
NGVVLVTREMLKRLAAD