Protein Info for GFF7287 in Variovorax sp. SCN45

Annotation: Dipeptide ABC transporter, ATP-binding protein DppF (TC 3.A.1.5.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 344 PF00005: ABC_tran" amino acids 37 to 186 (150 residues), 114.2 bits, see alignment E=7.9e-37 TIGR01727: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain" amino acids 236 to 318 (83 residues), 84.1 bits, see alignment E=2.8e-28 PF08352: oligo_HPY" amino acids 238 to 299 (62 residues), 67.4 bits, see alignment E=1.1e-22

Best Hits

Swiss-Prot: 56% identical to DPPF_HAEIN: Dipeptide transport ATP-binding protein DppF (dppF) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K12372, dipeptide transport system ATP-binding protein (inferred from 92% identity to vpe:Varpa_0424)

MetaCyc: 56% identical to dipeptide ABC transporter ATP binding subunit DppF (Escherichia coli K-12 substr. MG1655)
ABC-8-RXN [EC: 7.4.2.9]

Predicted SEED Role

"Dipeptide transport ATP-binding protein DppF (TC 3.A.1.5.2)" in subsystem ABC transporter dipeptide (TC 3.A.1.5.2) (TC 3.A.1.5.2)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (344 amino acids)

>GFF7287 Dipeptide ABC transporter, ATP-binding protein DppF (TC 3.A.1.5.2) (Variovorax sp. SCN45)
MSEASTGVVVEATNLQRTYDIRRGLFRAPSHLRAVGDISFRIERGRTLAVVGESGCGKST
LARMVALIEKPTAGQLTLVGTDAVDTPAERKRELRQAVQLVFQNPYGSLNPRKKISAVLE
DPLAINTTMGKQERAAKAREMLARVGLRPEYANRYPHMFSGGQRQRIAIARALMLNPRLL
VADEPVSALDVSIQAQVLNLLADLQAELGLAYLFISHDLGVVRHIAHDVLVMYLGHAVEQ
GPKSRIFSRPLHPYTQALLASTPGLSSQRIVLKGELPSPLNPPAGCVFSTRCPHVAERCR
QERPLPRMLDERLVACHYSEKFLDGAPLVRADVPSAAIAMATNL