Protein Info for GFF7286 in Variovorax sp. SCN45

Annotation: Dipeptide ABC transporter, ATP-binding protein DppD (TC 3.A.1.5.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 PF00005: ABC_tran" amino acids 24 to 182 (159 residues), 109.3 bits, see alignment E=3.8e-35 TIGR01727: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain" amino acids 231 to 316 (86 residues), 74.7 bits, see alignment E=2.5e-25 PF08352: oligo_HPY" amino acids 233 to 296 (64 residues), 60.2 bits, see alignment E=3.1e-20

Best Hits

Swiss-Prot: 57% identical to DPPD_ECOLI: Dipeptide transport ATP-binding protein DppD (dppD) from Escherichia coli (strain K12)

KEGG orthology group: K12371, dipeptide transport system ATP-binding protein (inferred from 93% identity to vpe:Varpa_0423)

MetaCyc: 57% identical to dipeptide ABC transporter ATP binding subunit DppD (Escherichia coli K-12 substr. MG1655)
ABC-8-RXN [EC: 7.4.2.9]

Predicted SEED Role

"Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2)" in subsystem ABC transporter dipeptide (TC 3.A.1.5.2) (TC 3.A.1.5.2)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (342 amino acids)

>GFF7286 Dipeptide ABC transporter, ATP-binding protein DppD (TC 3.A.1.5.2) (Variovorax sp. SCN45)
MPLLDIKDLHVEFPTQGGVLHAVDGVSLTLEEGEVLGIVGESGSGKSVTMMALMGLVGFP
GRVRAEHMRFAGKELLGISDKARRSLVGKEVAMIFQEPTTSLNPCFTIGFQLMETLRLHL
KLDKREAKRRATELLEQVGIPAASSRLGSYPHQLSGGMNQRVMIAMAIACNPRLLIADEP
TTALDVTIQAQILDLLRDLQKERGMALVLITHNMGVVSEMAQRIAVMYAGQVMEHQRVDH
LFASPQHPYTEALLAALPERVAPEGRLATISGMVPGVHDRPAGCLFAPRCSYVTERACHV
RPALREWQGAEVRCHFPLGEPGRKAAIESDPPRRRATDKVLP