Protein Info for GFF7270 in Variovorax sp. SCN45
Annotation: Altronate dehydratase (EC 4.2.1.7)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 49% identity to bgd:bgla_1g16680)Predicted SEED Role
"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)
MetaCyc Pathways
- D-galacturonate degradation I (3/5 steps found)
- superpathway of hexuronide and hexuronate degradation (6/10 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.7
Use Curated BLAST to search for 4.2.1.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (432 amino acids)
>GFF7270 Altronate dehydratase (EC 4.2.1.7) (Variovorax sp. SCN45) MSTSMNTPSPGESRLAPNVPRASRHANDVPQQAHLEFQGYVRPDGRVGTRNHIGIFVVGN CGATTARMVADHFTSKRLASYGNVDGVVPFVHELGCGMEMTGEPMNLLRRTIAGTIRNPN IVGAVVIALGCERNNIRGFFEQEKLVAGPMLHMIVMQEIGGTANAVAAGIAAVEEMLPMA DACQREPVPARHLVVGLQSAAVDDLAARSANPVLGAAVDLLVEAGGTAILSETSDLAALQ EQVARRAASAQVGGRIAQRIHWWKTYTHGRDTQLTRTSGSNPGGMASSADNAISGFLRAG SSPIQAVLEYAHPVNANGLVLMDAPAYAAVSATGQVASGANLVALTTGLGSTFGAAGVPT VKLVSNSAAFARMEDDSDIDCGPVLDGSTGVLEMAQVVLQRWLEYASGELTKSEELGVGD NEYVPWPIGVLA