Protein Info for GFF727 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Dipeptide transport ATP-binding protein DppD in protein degradation cluster

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 623 PF00005: ABC_tran" amino acids 33 to 197 (165 residues), 102.3 bits, see alignment E=1.3e-32 amino acids 340 to 491 (152 residues), 111.2 bits, see alignment E=2.2e-35 PF08352: oligo_HPY" amino acids 248 to 287 (40 residues), 31.6 bits, see alignment 6e-11 amino acids 543 to 575 (33 residues), 35.9 bits, see alignment (E = 2.7e-12)

Best Hits

Swiss-Prot: 100% identical to GSIA_SALTY: Glutathione import ATP-binding protein GsiA (gsiA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K13892, glutathione transport system ATP-binding protein (inferred from 100% identity to see:SNSL254_A0916)

MetaCyc: 84% identical to glutathione ABC transporter ATP binding subunit GsiA (Escherichia coli K-12 substr. MG1655)
RXN0-11 [EC: 7.4.2.10]

Predicted SEED Role

"Dipeptide transport ATP-binding protein DppD in protein degradation cluster"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (623 amino acids)

>GFF727 Dipeptide transport ATP-binding protein DppD in protein degradation cluster (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
VPHSDELDSRDVLSVSGLNIAFHHEGQQVDAVRNVSLRLKRGETLAIVGESGSGKSVTAL
ALMRLIEQSGANVRCGEMLLRRRNRQVIELSEQSDAQMRRVRGADIAMIFQEPMTSLNPV
FTVGEQIAESIRLHQGASHEEALAEAKRMLDQVRIPESQAILSRYPHQLSGGMRQRVMIA
MALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQQEMSMGVIFITHDMGVVADIADRVL
VMYQGEAVETGSVEQIFHAPTHPYTQTLLAAVPQLGAMRGHSLPRRFPLISADEPALYES
QIEQDTVVEGEPILQVRGLVTRFPLRSGLFNRVTREVHAVENISFDLWPGETLSLVGESG
SGKSTTGRALLRLVESRQGEIIFNGQRIDTLSAGKLQPLRRDIQCIFQDPYASLDPRQTV
GYSIMEPLRIHGLGQGDAAAKRVAWLLERVGLRPEHAWRYPHEFSGGQRQRICIARALAL
NPKVIIADEAVSALDVSVRGQIINLLLDLQREMGIAYLFISHDMAVVERISHRVAVMYLG
QIVEMGPRRAVFENPQHPYTRKLMAAVPVADPSRHRPRRVLLSDDIPSNIHKRGEETPAV
SLQLVGPGHYVARPLQDNALSRL