Protein Info for GFF7269 in Variovorax sp. SCN45

Annotation: Altronate dehydratase (EC 4.2.1.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 34 to 102 (69 residues), 40.2 bits, E=6.2e-14
• PF04295: GD_AH_second
  • amino acids 133 to 274 (142 residues), 118.7 bits, E=3.2e-38
• PF20629: GD_AH_C
  • amino acids 285 to 524 (240 residues), 317.9 bits, E=5.9e-99

Best Hits

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 60% identity to axy:AXYL_01531)

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• D-galacturonate degradation I (3/5 steps found)
• superpathway of hexuronide and hexuronate degradation (6/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.7

Use Curated BLAST to search for 4.2.1.7

Protein Sequence (528 amino acids)

>GFF7269 Altronate dehydratase (EC 4.2.1.7) (Variovorax sp. SCN45)
MTTTAKPITPTLSSTVKPSDAVLRNPFIRLDPKDNVVVARMEVPAGTPVPAEGVTTLQAV
PAGHKMATRAIAKGAPVLKYNTVIGFASEDLPAGTWMHSHNIAFGDLVKDYRHGLDYAPT
VLLSPGDRARFHGIVRADGRVATRNYIGVFIVSHSGATVARQIARFFDADELAAYPHVDG
VVPYIHEQGSGMERSGEPMDMLRRTIGGYVKHPNTAGALVIALGQEHNELEAFLEHQGLV
RGPMLQTLVIQDAGGTKKAIAAGIEIVRAMLPQADTARRESVSAEHIMVGMQCGGSDGFS
GLSANPALGAAMEILIRNGGTAILSETSEIYGVEHTLTARARTPEIGQKLVARIDWWLEY
NKGRDTQINGQVSPGNNAGGLANVLEKSLGGAKKGGNAPLMEVYEYAQPVTQHGLVFMDT
PGYDPVSATGQIAGGANLICFTTGRGSCFGSVPSPTIKLASNTPMYARMEPDMDINCGPV
IDGDATIADMGQRIFEQVLRHASGEKTKSEALGVGLNEFVPWPLGIAD