Protein Info for GFF7267 in Variovorax sp. SCN45
Annotation: L-talarate dehydratase @ Galactarate dehydratase (EC 4.2.1.42)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 75% identical to TAGAD_SALTY: L-talarate/galactarate dehydratase (STM3697) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG orthology group: None (inferred from 76% identity to efe:EFER_1473)Predicted SEED Role
"L-talarate dehydratase @ Galactarate dehydratase (EC 4.2.1.42)" (EC 4.2.1.42)
MetaCyc Pathways
- D-galactarate degradation II (3/3 steps found)
- superpathway of D-glucarate and D-galactarate degradation (4/5 steps found)
- D-galactarate degradation I (3/4 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.42
Use Curated BLAST to search for 4.2.1.42
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (399 amino acids)
>GFF7267 L-talarate dehydratase @ Galactarate dehydratase (EC 4.2.1.42) (Variovorax sp. SCN45) MASAVESNIVSYAKVAEGARTAAETGDRIDSVKVSLIFLPLATPVSDAKVLTGRQKPLTE IAFIFAEIRTRDGLDGIGFGYSKRAGGPGMYAHAKEIAPNLLGEDPSDIQKIFTKLLWAG ASMGRSGMTTQAIAPFDIALWDLKSKRAKLPLAKLLGAHRDSVQCYNTSGGYLHTPLDQV LKNVEISQRSGIGGIKLKVGQPDLSIDIERVGAVRKLLGDSFPLMVDANQQWDRQKATRA CRAFEGFDLTWIEEPLDAYDFEGHAQLATRFDTAIATGEMLTSAGEHAQLILAEGSDFIQ PDAPRVGGITPFLEIMALGAMKGRKLAPHFAMEIHLHLAAAYPIEPWLEHFEWLGPMFNE QMHLQDGRMHVSDRHGLGFSLSEQAISWRADSETFGKAS