Protein Info for GFF7246 in Variovorax sp. SCN45

Annotation: HtrA protease/chaperone protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 479 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00089: Trypsin" amino acids 88 to 233 (146 residues), 44.1 bits, see alignment E=5.8e-15 PF13365: Trypsin_2" amino acids 90 to 223 (134 residues), 109.9 bits, see alignment E=4.9e-35 PF13180: PDZ_2" amino acids 263 to 351 (89 residues), 44.5 bits, see alignment E=4.1e-15 amino acids 379 to 457 (79 residues), 33 bits, see alignment E=1.6e-11 PF17820: PDZ_6" amino acids 289 to 342 (54 residues), 43 bits, see alignment 8e-15

Best Hits

Predicted SEED Role

"HtrA protease/chaperone protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (479 amino acids)

>GFF7246 HtrA protease/chaperone protein (Variovorax sp. SCN45)
MKAAALARCLAAIAFGAFALASATQAWSQARSCLERAPSVPQAADFAAAAARQSPAVVSI
MVTENGGERPVAGDMRPSMPWEKAWGRGFASGFIIGNDGYILTSAHAVTGVQAISVVTAD
QRRFDGEVVGIDRLSDVALLKVPASGLPVVVLGHGSDLCPGERVAAMGAPFGFERSVTAG
VVSANPRYIPGGSGVPLIQSDVALNPGNSGGPLFNERGEVVGMNSMIYSPGGGYFGMSFS
LPIDTVMRVVDELRATGHVRRGHIGARTQPLTAELAPAFGLASTQGALIVRVDPDSPAAA
AGLRSGDVVLAVGADTAMSYADIQNRVAAAHQGSRIELKVWRHRAPLTVQVGVVENPPDA
SPRPAARAVVQEARFGLELVERKGVLGISLPSPGLYVQSVSGSAQMVGLRYGDMLIAVND
VEVACLADFDAAIRSVTENDTVALLVMRGSARSYVPILPRSAQRTPVERRAGEVAGSMP