Protein Info for GFF7191 in Variovorax sp. SCN45

Annotation: Acyl-CoA dehydrogenase; probable dibenzothiophene desulfurization enzyme

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 393 TIGR04022: sulfur acquisition oxidoreductase, SfnB family" amino acids 3 to 392 (390 residues), 608.1 bits, see alignment E=3.3e-187 PF02771: Acyl-CoA_dh_N" amino acids 14 to 115 (102 residues), 46.6 bits, see alignment E=8.4e-16 PF02770: Acyl-CoA_dh_M" amino acids 124 to 208 (85 residues), 35.9 bits, see alignment E=1.4e-12 PF00441: Acyl-CoA_dh_1" amino acids 235 to 366 (132 residues), 42 bits, see alignment E=2.3e-14 PF08028: Acyl-CoA_dh_2" amino acids 236 to 368 (133 residues), 66.8 bits, see alignment E=4.8e-22

Best Hits

KEGG orthology group: K00253, isovaleryl-CoA dehydrogenase [EC: 1.3.99.10] (inferred from 59% identity to bur:Bcep18194_C7712)

Predicted SEED Role

"Acyl-CoA dehydrogenase; probable dibenzothiophene desulfurization enzyme"

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.10

Use Curated BLAST to search for 1.3.99.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (393 amino acids)

>GFF7191 Acyl-CoA dehydrogenase; probable dibenzothiophene desulfurization enzyme (Variovorax sp. SCN45)
MTAHLIRTDAEALTVARALAAEFAPTASGRDRERRLPHAEVDRFSASGLWGITVPRAFGG
AAVSHVTLAEVIALISEADPALGQIPQNHHCLVDAVRLIGSPAQQDFFFREALEGKRFGN
AVSESGTPNAKVVTARLSRSPEGLRLNGRKFYCTGALFAHWVPVAAKDEEDRQVLVYVRR
NAPGLEVIDDWSGFGQRTTASGTVTAEHVAVEPLQVLPRAQLFDPPTIHGPFAQILHAAI
DLGIGRAAMADLRTWVRDRARPWPDSGVSRAADDPLTLAKLGELVIQQHAAEALVERSGR
YLDEARDHSTPERVTEASIAVAEAKFVTTEFALRAATTLIELGGTQATLAEHNLDRHWRN
ARTHTVHDPARWKPHAVGNHWLNGATPQRHASL