Protein Info for GFF7172 in Variovorax sp. SCN45

Annotation: Manganese transport protein MntH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 441 transmembrane" amino acids 66 to 91 (26 residues), see Phobius details amino acids 112 to 132 (21 residues), see Phobius details amino acids 138 to 160 (23 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details amino acids 213 to 233 (21 residues), see Phobius details amino acids 256 to 283 (28 residues), see Phobius details amino acids 304 to 322 (19 residues), see Phobius details amino acids 352 to 370 (19 residues), see Phobius details amino acids 376 to 397 (22 residues), see Phobius details amino acids 418 to 438 (21 residues), see Phobius details TIGR01197: metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family" amino acids 32 to 406 (375 residues), 374.2 bits, see alignment E=4.8e-116 PF01566: Nramp" amino acids 54 to 412 (359 residues), 452.5 bits, see alignment E=5.3e-140

Best Hits

Swiss-Prot: 69% identical to MNTH_RALSO: Divalent metal cation transporter MntH (mntH) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K03322, manganese transport protein (inferred from 93% identity to vpe:Varpa_5969)

Predicted SEED Role

"Manganese transport protein MntH" in subsystem Transport of Manganese

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (441 amino acids)

>GFF7172 Manganese transport protein MntH (Variovorax sp. SCN45)
MFFPLPRTATAPFCPSEVKGSVAVPQELPFFRKLMRYAGPGLLVSVGYMDPGNWATDIEA
GSRFGYGLLFVVLLASLAAMLLQTLCVRLGLVARKDLARACREHYSPRVNRFLWLGAELA
IVACDLAEVLGSALALHLLFGVSIPVGIAITAFDTLLVLGLQGAGFRRVEAIVLGLVGTI
AGCFAVELMMAPPNWFGVAMGFAPSLERLHQPGALYLAIGIVGATVMPHNLYLHSSIVQT
RLVADTEPARREAVRFCTLDAVVSLSLALLVNAAIMVLAASAFHATGHREVAEIDDAYRL
LEPVVGSAFAATLFGIALLASGQSSTFTGTIAGQIIMEGFLDLKIPCWQRRLITRALALG
PAFLGVWWFGDGGVGKMLVLSQVVLSFQLPFAMWPLIRFTSSRAMMGGFANGPVLKSLAW
GLFSVIGAANMWLVASVLSGG