Protein Info for GFF7139 in Variovorax sp. SCN45

Annotation: MATE efflux family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 transmembrane" amino acids 24 to 49 (26 residues), see Phobius details amino acids 60 to 86 (27 residues), see Phobius details amino acids 106 to 124 (19 residues), see Phobius details amino acids 144 to 165 (22 residues), see Phobius details amino acids 177 to 197 (21 residues), see Phobius details amino acids 203 to 223 (21 residues), see Phobius details amino acids 244 to 268 (25 residues), see Phobius details amino acids 288 to 309 (22 residues), see Phobius details amino acids 323 to 347 (25 residues), see Phobius details amino acids 359 to 380 (22 residues), see Phobius details amino acids 391 to 411 (21 residues), see Phobius details amino acids 417 to 440 (24 residues), see Phobius details PF01554: MatE" amino acids 33 to 191 (159 residues), 70.6 bits, see alignment E=6.4e-24 amino acids 250 to 411 (162 residues), 55.8 bits, see alignment E=2.3e-19

Best Hits

KEGG orthology group: None (inferred from 87% identity to vpe:Varpa_5940)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (484 amino acids)

>GFF7139 MATE efflux family protein (Variovorax sp. SCN45)
MPITETAAGAGRPRFVSGSLMRHVCVMAGTGAIGLIAVFAVDLINLFYISLLGEKETAAA
VGFAGVVGFFHASLCIGLTIGIAAVVSRTVGAGRMDDARRIGTSSLVLMVALSVLAGTGT
AFFLHPALQALGAQGETARLAHRYLSVTVHTLPLLGIGMATSALLRSVGDARRSMTVTLA
GAFVTAVLDPILIFGFGLGLDGAAISAVVSRTALAALGLHGVLVKHRMLGPFQASRLGAD
ARALGSVAGPAVLTNLATPVGAAFVTHAVAQFGPSAVAGAATIDRLTPVAFGLVYALSGA
VGPILAQNLGAGQYRRVQEGLRASLLFMVASVAVAWLLLALGQGLLVRAFSAEGQAAELI
SLFCSWLAASFFFAGGLFVANASFNNLGHPLLSTGFNWGRATLGTIPFAWWGSHYGAAGV
LIGQAVGSSIFGLLAVVVAFRLAAKLARQEAPDAAPAPVLDAPVAPTSALATPQPAVTAP
AAAP