Protein Info for GFF7118 in Variovorax sp. SCN45

Annotation: 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04166: PdxA
  • amino acids 54 to 303 (250 residues), 247 bits, E=1.4e-77

Best Hits

KEGG orthology group: K00097, 4-hydroxythreonine-4-phosphate dehydrogenase [EC: 1.1.1.262] (inferred from 49% identity to pdx:Psed_0074)

Predicted SEED Role

"4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.262)

MetaCyc Pathways

• pyridoxal 5'-phosphate biosynthesis I (6/7 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (7/12 steps found)

KEGG Metabolic Maps

• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.262

Use Curated BLAST to search for 1.1.1.262

Protein Sequence (313 amino acids)

>GFF7118 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) (Variovorax sp. SCN45)
MTVRLAIAIGDPNGIGPEIAVKAAAATAHDVRIVLVGDAIVIEDNLRRYAPAGHRIDVCA
TPSLGPADYVPGQLSAAAGAATVEYVRQAVKLAQSEEVDAVMSCPCSETAVNMAGIPFAG
FQPLIAELTGTARDDTFMMLVADGLRIAHVTLHEGVASAMARMTPALVARAARATDKALR
SLGCANPRIAMFGINPHAGENGLFGSEDERVTKPAAALLQGEGLGIEGPFPADLVLSQRK
HDAYLAMFHDQGHIPIKLVSPLRATSLTIGTPILFASVAHGCAHDIAGTGQADPIAMQLA
IALLADNIQRSHE