Protein Info for GFF7097 in Variovorax sp. SCN45

Annotation: Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 21 to 479 (459 residues), 573.8 bits, E=1.2e-176
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 32 to 478 (447 residues), 696.4 bits, E=8.3e-214

Best Hits

Swiss-Prot: 65% identical to DAVD_PSEAE: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 83% identity to dac:Daci_0100)

MetaCyc: 65% identical to glutarate semialdehyde dehydrogenase (Pseudomonas aeruginosa)
Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.20]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16)

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• L-lysine degradation X (4/6 steps found)
• L-lysine degradation IV (2/5 steps found)
• L-lysine degradation I (3/7 steps found)
• L-lysine degradation III (1/6 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20

Protein Sequence (484 amino acids)

>GFF7097 Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) (Variovorax sp. SCN45)
MLNQLRDPSLLKSACLVNGVWLAADNGTTLDVTNPSTGAVIGTVPNMAQAETQRAIDAAD
RAFRGWRRETADSRAMVLRRWFELLMQHQEDLALIMTTEQGKPLTESRGEIAYAASYIQW
FGEEARRIYGSVVPSPWADKQIIVIKEPVGVCAAITPWNFPAAMITRKVAPALAAGCTII
VKPAQQTPLTALALAELAVRAGVPAGVLSVLTGSSRAIGGVLTGSMDVRKLTFTGSTEVG
RVLAEQCAPTLKKMSLELGGNAPFIVFDDADLDAAVVGAMASKYRNTGQTCVCANRLLVQ
EGVYDAFMAKLKVAVEALKVGDGLTPDAEQGPLIDQGALDKVEELVADALSQGAGLVSGG
KRHALGGTFYEPTILGNATPAMRIANEEVFGPVAAVFRFKTEGEAIQMANDTEYGLAAYF
YARDIGRVWRVGGALEYGMVGINSGIISTAVAPFGGVKQSGIGREGGEAGIEEYVSTKYL
CMGS