Protein Info for GFF703 in Variovorax sp. SCN45

Annotation: Efflux ABC transporter, permease/ATP-binding protein Atu2242

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 618 transmembrane" amino acids 40 to 63 (24 residues), see Phobius details amino acids 83 to 103 (21 residues), see Phobius details amino acids 155 to 177 (23 residues), see Phobius details amino acids 183 to 202 (20 residues), see Phobius details amino acids 263 to 310 (48 residues), see Phobius details PF00664: ABC_membrane" amino acids 43 to 307 (265 residues), 60.7 bits, see alignment E=1.9e-20 PF00005: ABC_tran" amino acids 378 to 531 (154 residues), 119 bits, see alignment E=2.4e-38

Best Hits

Swiss-Prot: 58% identical to Y1051_HAEIN: Uncharacterized ABC transporter ATP-binding protein HI_1051 (HI_1051) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K06147, ATP-binding cassette, subfamily B, bacterial (inferred from 94% identity to vpe:Varpa_2432)

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (618 amino acids)

>GFF703 Efflux ABC transporter, permease/ATP-binding protein Atu2242 (Variovorax sp. SCN45)
LFRFFEKLLHPYPAAEPSLPPQGFFAFLWACTHGVRGKIAAMAVLTAVMSIFEAALFAIL
GRIVDWLGGQVPSRLWEDRGTTLMWLAAFLVISIGVVALQTIVKHQTLAVNLPMRLRWNF
HRLMLGQSMAFYQDEFAGRITAKVMQTALAVRETIFVLADVLVAMGVYVATMIILVGVLD
AQLVWPFLIWLVLYVVSLIYFVPRLGKVGKAQADARALMTGRVTDAYTNIATVKLFSHTQ
REAGFARDAMREFMHTGYGQMRLVSAFEIVNHTLSMGLTAGMAGMALWLWSNGAVGVGAV
AAATAMALRLQGMSHWIMWEMTSLFENIGTVQDGMKTLSRPRTVLDAADATVLQVPQGEV
RFEHASFRYGDGGRRVIDDLNLTVKPGEKIGLVGRSGAGKSTLVNLLLRFHDLESGRILI
DGQDIAHVTQDSLRSHIGMVTQDTSLMHRSVADNVAYGRPDATREQIEAAARRAEAHDFI
QTLGDAGGRRGYEAHVGERGVKLSGGQRQRVAIARVMLKDAPILLLDEATSALDSEVEAA
IQQSLYTLMEGKTVIAIAHRLSTIAAMDRLIVLDEGRVVEEGDHRTLMAQGGLYARLWAH
QSGGFLGEGLDEDEALRA