Protein Info for GFF7013 in Variovorax sp. SCN45

Annotation: Taurine ABC transporter, substrate-binding protein TauA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 336 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details TIGR01729: taurine ABC transporter, periplasmic binding protein" amino acids 32 to 330 (299 residues), 355.7 bits, see alignment E=1.1e-110 PF13379: NMT1_2" amino acids 40 to 242 (203 residues), 39.8 bits, see alignment E=1e-13 PF12974: Phosphonate-bd" amino acids 52 to 199 (148 residues), 36.4 bits, see alignment E=7.9e-13 PF04069: OpuAC" amino acids 52 to 238 (187 residues), 45.6 bits, see alignment E=1.4e-15 PF09084: NMT1" amino acids 66 to 243 (178 residues), 68.5 bits, see alignment E=1.6e-22

Best Hits

Swiss-Prot: 37% identical to TAUA_ECOLI: Taurine-binding periplasmic protein (tauA) from Escherichia coli (strain K12)

KEGG orthology group: K02051, sulfonate/nitrate/taurine transport system substrate-binding protein (inferred from 91% identity to vpe:Varpa_4432)

MetaCyc: 37% identical to taurine ABC transporter periplasmic binding protein (Escherichia coli K-12 substr. MG1655)
ABC-64-RXN [EC: 7.6.2.7]

Predicted SEED Role

"Taurine-binding periplasmic protein TauA" in subsystem Taurine Utilization

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (336 amino acids)

>GFF7013 Taurine ABC transporter, substrate-binding protein TauA (Variovorax sp. SCN45)
MTLSRRLSLQCAAALATAFTLSGAVFAQTKEVTFAHQDMLVPLRLVMESGEVEKATGYKI
NWRMFAGGGDVIRAMASGDVQMGETGSSPLTAAASQGQDIKLFWISADIANAEALVARNG
TNINSIKDLAGKKVATPFVSTAHYQLMAGMKMDGVDAKSVNVMNMRPPEIAAAWERGDID
ATFIWDPVLSKIKANGKTIATSGSIGKRGAPTFEGIVVNAKWAAANEPFMVAFVKALNRA
NEEYKATGKSWTPDSPQTKAMAKWTKADPKDVGAAMALYTFPTMAEQVSPTWLGGGAAKA
MANTAAFLKEQGRVQEVKPDYSAFVTTAYVDKAMGK