Protein Info for GFF701 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Sensory histidine kinase QseC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 147 to 174 (28 residues), see Phobius details PF08521: 2CSK_N" amino acids 21 to 146 (126 residues), 43.3 bits, see alignment E=5.8e-15 PF00512: HisKA" amino acids 224 to 287 (64 residues), 48.3 bits, see alignment E=1.3e-16 PF02518: HATPase_c" amino acids 336 to 443 (108 residues), 86.7 bits, see alignment E=2.3e-28

Best Hits

KEGG orthology group: K02484, two-component system, OmpR family, sensor kinase [EC: 2.7.13.3] (inferred from 64% identity to rfr:Rfer_3821)

Predicted SEED Role

"Sensory histidine kinase QseC" in subsystem Orphan regulatory proteins

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>GFF701 Sensory histidine kinase QseC (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNLPTHSLRARLIGLLLLAIVLAAGLQVAVVYRQARAEADGIFDYHMEQMAQALRAGVLP
PGPPVAGDEPPLPAEAFDFFVQVWTQEGLRVFQSGTAAALPQRAVLGFSNIEVDGKPYRV
YSMQSRTQVIQVAQDLRPRQTMARALAWRTVLPIAWMAPLLMLVAWAVVSASLAPVARVR
RQVAAREADELAEVSEAGLPDEIRPLVHELNLLFGRVRQAFDAQKNFVAEAAHELRSPLA
ALRLQVQGLQRAPDDATRQLATERLLAGIDRATRLVEQLLVLARQQAQPSSGEPAQPVSL
ADLAAQAVADAVPLAASRRIDLGLGDADAGQVNGHAEPLRILLGNLVDNALKYTPEGGTV
DVAVRRDKDQLVLSVEDSGPGIPEADRARVLDRFYRVPGSTATGSGLGLAIANAIAQLHG
AALALDRSPRLGGLRIAVRLPLRTV