Protein Info for GFF6966 in Variovorax sp. SCN45

Annotation: Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 776 transmembrane" amino acids 135 to 154 (20 residues), see Phobius details amino acids 174 to 192 (19 residues), see Phobius details amino acids 204 to 224 (21 residues), see Phobius details amino acids 236 to 254 (19 residues), see Phobius details amino acids 389 to 410 (22 residues), see Phobius details amino acids 416 to 441 (26 residues), see Phobius details amino acids 726 to 742 (17 residues), see Phobius details amino acids 748 to 767 (20 residues), see Phobius details PF00403: HMA" amino acids 57 to 105 (49 residues), 41.3 bits, see alignment 2.5e-14 TIGR01511: copper-translocating P-type ATPase" amino acids 189 to 768 (580 residues), 430.9 bits, see alignment E=1.8e-132 TIGR01525: heavy metal translocating P-type ATPase" amino acids 206 to 768 (563 residues), 489.1 bits, see alignment E=4.4e-150 TIGR01494: HAD ATPase, P-type, family IC" amino acids 244 to 510 (267 residues), 124.5 bits, see alignment E=8.2e-40 amino acids 581 to 744 (164 residues), 109.7 bits, see alignment E=2.6e-35 PF00122: E1-E2_ATPase" amino acids 274 to 449 (176 residues), 163 bits, see alignment E=8.3e-52 PF00702: Hydrolase" amino acids 466 to 680 (215 residues), 91.3 bits, see alignment E=1.7e-29

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 78% identity to vap:Vapar_2816)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (776 amino acids)

>GFF6966 Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4) (Variovorax sp. SCN45)
MNATFAPDRVAIPALPTAAAAASEEAWQVLDDPAEWPAFGRELDAADGGHWESQVVVEGM
HCAACAFTVEAALRQVPGVSEAQVNAASRRARVVWSPAQTLPSRWFEASAKAGYRLLPGS
DRFVRELRRRESRLALWRWLVSGFCMMQVMMYAYPGYVARPGDMGADSALLLRWASWVLT
LPVVLFSCGPFFRSAWRDLRLGRIGMDLPVAFGVLVTFAVSSAATFDAGGPLGHEVYFDS
LTMFVFFLLTGRWLEARLRERTAGALDALMNRLPDSIDRLAADGGWTRVAVRRLAVGDLV
RVRPGEAFPADGVVIEGDTSADEALLTGESRPVPRPCGDRVLAGSHNLSAPVRVRIESVG
EGTRFAQIVRLMESAASRKPRLALLADRVARPFLVVVVASAAVAATLWWPTDPGRALMVA
VAVLIVTCPCALSLATPAAMLASAGTLARGGVMTSNLQALEALASVDTVVFDKTGTLTGD
VPRMERIYCRQGLRPGDALEVAAALAAQSLHPVAQALVNAWNAQFRSAPGWTAEQVAETA
GQGIEGRMRRVRAPVDTGRHVRLGSAGFCDVAALEVDAAQVHLADEQGWLASFVLTEEPR
ADAAAAVAALRAEGLTVRLLSGDRVAAAREIAARCGIDFAQGGCTPEDKLDVLWRLQAEG
RQIAMVGDGLNDGPSLARADASFAFGRSVPLSRAHADFVVLGDRLASIPQAIAQARRTLR
VVRQNLFWAAGYNALCVPLAIAGWLPAWLAGLGMAASSLVVILNAARLSRGGEGAR