Protein Info for GFF6946 in Variovorax sp. SCN45

Annotation: Sensory box histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 705 TIGR00229: PAS domain S-box protein" amino acids 28 to 143 (116 residues), 77.3 bits, see alignment E=5.8e-26 PF13188: PAS_8" amino acids 29 to 78 (50 residues), 29.2 bits, see alignment 3.4e-10 PF00989: PAS" amino acids 30 to 140 (111 residues), 42.2 bits, see alignment E=4e-14 PF08448: PAS_4" amino acids 35 to 141 (107 residues), 34.5 bits, see alignment E=1.1e-11 PF13426: PAS_9" amino acids 37 to 140 (104 residues), 48 bits, see alignment E=7.4e-16 PF24820: Diguanyl_cycl_sensor" amino acids 38 to 139 (102 residues), 31.8 bits, see alignment E=6.5e-11 PF13185: GAF_2" amino acids 169 to 309 (141 residues), 65 bits, see alignment E=4.7e-21 PF13492: GAF_3" amino acids 171 to 311 (141 residues), 45.2 bits, see alignment E=7e-15 PF01590: GAF" amino acids 171 to 309 (139 residues), 63 bits, see alignment E=2.5e-20 PF00512: HisKA" amino acids 328 to 392 (65 residues), 34.8 bits, see alignment E=7.4e-12 PF02518: HATPase_c" amino acids 436 to 561 (126 residues), 58.7 bits, see alignment E=4e-19 PF00072: Response_reg" amino acids 584 to 696 (113 residues), 49.2 bits, see alignment E=3.1e-16

Best Hits

KEGG orthology group: None (inferred from 80% identity to vap:Vapar_5580)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (705 amino acids)

>GFF6946 Sensory box histidine kinase/response regulator (Variovorax sp. SCN45)
MADAAGDPLQLPGAPGQVLPSGIDEGSVFRSLFAAYPDSLLVVDQTGRIVLANPSAATLL
GYAQNELVGLNVEALVPDSIRPRHASYREAYGRAPRPRPMGTHMELVAKRKDGSEVMVEI
ALSPLQNHGLPFVVAAIRDIGAYPRVKQALQRARYSEHLAQLGRLAVDTRDLQAVLEHVP
EIITKALEVEVAMVWLLDASRAEFRVASGVGLVAGEEIGARMVNRPDTPPGFVLSQGRPV
VVQDYGKELRFSVPKAYLEAGLVSALAVPLSDRGRVIGMLSVRSTESKRFGDEEVRFLES
LSSLLATSLQRTQTEEALNHAQRLESVGQLTGGIAHDFNNLLTVIQGNLQVLEELPALAQ
DGYAQQLLGAATRASRRGAELTGKLLAFSRRQVLQPVAVDTHALLYSLADMLRRTLDQRI
GIEIDTAPGRPLVVADPGQLESALLNIAINARDAMPEGGTLHFRTAICGALPAILRNQRN
DPQGSAAAHFVAISIADSGSGMTDDVKERAFEPFFTTKEAGRGTGLGLSTVYGFVNQSRG
AVAIDSEIGQGTTVTLYLPQQEEARAPAAAEEHAGEALPAGLRVMLVEDDAEVRKVVENF
LCTLGCEIVIAASTAEQALATLDTGTEPFDLLLSDIALGAGMRGTRLAAEIRQRFPRVAV
LLMSGFSSELLDADREVPQGWELLRKPYTRSELARAMARVLTGNA