Protein Info for GFF688 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Cytochrome c oxidase polypeptide II (EC 1.9.3.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 401 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details transmembrane" amino acids 67 to 90 (24 residues), see Phobius details amino acids 110 to 130 (21 residues), see Phobius details PF02790: COX2_TM" amino acids 49 to 132 (84 residues), 43 bits, see alignment E=8.4e-15 TIGR02866: cytochrome c oxidase, subunit II" amino acids 59 to 282 (224 residues), 187.8 bits, see alignment E=8.2e-60 PF00116: COX2" amino acids 145 to 273 (129 residues), 125 bits, see alignment E=3e-40 PF00034: Cytochrom_C" amino acids 306 to 381 (76 residues), 37.9 bits, see alignment E=7.5e-13 PF13442: Cytochrome_CBB3" amino acids 306 to 378 (73 residues), 47.7 bits, see alignment E=3.2e-16

Best Hits

KEGG orthology group: K02275, cytochrome c oxidase subunit II [EC: 1.9.3.1] (inferred from 78% identity to pna:Pnap_0878)

Predicted SEED Role

"Cytochrome c oxidase polypeptide II (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (401 amino acids)

>GFF688 Cytochrome c oxidase polypeptide II (EC 1.9.3.1) (Hydrogenophaga sp. GW460-11-11-14-LB1)
VSTTNKKVHSLRNRWAAIRAVATTLALGAGAWTTVAAQAVKDLAGGPAVNQLNFHPPVTR
IAEEQHWLHWFMMVLCAVIFVIVFGVMFYSILKHRKAAGHKAQDLPEPIWVELGWTIVPL
LIVIGMALPATKVLVAQKDTTNSDLTIKATGMQWKWGYDYIKGEGEGIGFLSTLDNNQRV
MSNSGKPEATDDYLLKVDNPLVVPVNKKIRIITTANDVIHAWMVPAFGVKQDAIPGFVRD
TWFRAEKTGDFYGQCAELCGKEHAYMPIHVKVVSAEEYTAWVTEKQKAMAAAADDPSKVW
TLTDLVKRGESVYAANCAACHQANGKGAGPIKPLDGSAIVTDTDHGKMINVVLHGAAGGA
MPSWKQLSDTELAAVMTFAKNNWSNKTEQIVQPAEVLAARK