Protein Info for GFF6862 in Variovorax sp. SCN45

Annotation: Two-component system sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 transmembrane" amino acids 23 to 46 (24 residues), see Phobius details amino acids 165 to 185 (21 residues), see Phobius details PF00672: HAMP" amino acids 185 to 233 (49 residues), 34.5 bits, see alignment 3.2e-12 PF02518: HATPase_c" amino acids 339 to 441 (103 residues), 89.9 bits, see alignment E=2.4e-29

Best Hits

KEGG orthology group: None (inferred from 80% identity to vpe:Varpa_0728)

Predicted SEED Role

"sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>GFF6862 Two-component system sensor histidine kinase (Variovorax sp. SCN45)
MPNTASLPAPAIGLRRLTPRSLFSRVTLIIVIGLAIAQLLTFAAIRYERGMALRELMMIG
IERDIASSVAILDRLPAAERESWLARLERRNYRFVLGGSAEGTPPDTAMSRQFAKAIVDA
MRPFQIVKVGQVSSPREGLQIEVRLSDGSTLVVHARRVDMPVSSWVMWLLWIQLLVLAVC
AWYAVRLVTRPLAQLADAADELGPDLKGQQLSEDGPTEVAHAARAFNAMQKRIAGYMAER
VEILAAISHDLQTPITRMRLRTDLMDNEQDRGKFRQDLDAMNALVREGVTYARTLHGATE
PPCRIDADALFESMLADYEDSGERVLLEGRAGAPIVTRPNALRRILTNLIDNALKFGTDV
RLQVRIDGDRLALLVVDNGPGIPPDDLENVLKPFYRVENSRNRSTGGTGLGLAIAHQLAM
AMGAELTLRNRDEGGLEARLTMYTRAALPG