Protein Info for GFF6781 in Variovorax sp. SCN45

Annotation: Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) / Aminodeoxychorismate lyase (EC 4.1.3.38)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00553: aminodeoxychorismate synthase, component I
  • amino acids 65 to 378 (314 residues), 346.8 bits, E=5.9e-108
• PF00425: Chorismate_bind
  • amino acids 123 to 375 (253 residues), 278.2 bits, E=7.4e-87
• PF01063: Aminotran_4
  • amino acids 392 to 586 (195 residues), 97.9 bits, E=8.3e-32

Best Hits

KEGG orthology group: K03342, para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC: 2.6.1.85 4.1.3.38] (inferred from 68% identity to pol:Bpro_0904)

Predicted SEED Role

"Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) / Aminodeoxychorismate lyase (EC 4.1.3.38)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 2.6.1.85, EC 4.1.3.38)

MetaCyc Pathways

• superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
• L-glutamate and L-glutamine biosynthesis (7/7 steps found)
• superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• 4-aminobenzoate biosynthesis I (2/2 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (3/4 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• 4-aminobenzoate biosynthesis II (1/2 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• superpathway of candicidin biosynthesis (4/11 steps found)
• chloramphenicol biosynthesis (2/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.85

Use Curated BLAST to search for 2.6.1.85 or 4.1.3.38

Protein Sequence (595 amino acids)

>GFF6781 Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) / Aminodeoxychorismate lyase (EC 4.1.3.38) (Variovorax sp. SCN45)
MQGDGKTLSGLSALIDFAEPRGDGARRLRMAFGAPSRVLVARTAGEVRPVLEAVEAMARE
GRWCVGYLRYEAATAFDPAFVVHEADGPLAWFGVHDQALPWPDVAPTAPTAPSVDWQCSL
PRAAFDQSMHAIHRTIANGELYQVNYTAALRAGFQGDAREWFLALRQAQPGGYTAFIDSG
EEQVLSVSPELFFDWQGERILARPMKGTAPRGATPAEDDAHALRLRTVPKERAENVMIVD
LIRNDLSRVARPFSVRVPRLFHTEALPTVWQMTSDVEALVRDGTSLADVFAALFPCGSIT
GAPKVSAMRLIRELEPEARGVYCGAVGVVRPGGHATFNVPIRTVTLRGNEARCGIGSGIT
ADAQADAEWEEWRHKRAFLSPTLRDERPPFDLLETLALVDGELRDAAAHLDRMANAARHF
DYAWNEALVAECLHRLQGRHTSGAWRVRLLLDARGTPRAEAFAMEAPPARVRLQLADRAF
DESGSDFTRFKTTRRAHYEAFAPTAPGVFDTLLWNREGEITECTRGNIALLLDGRWVTPP
LHCGLLGGIGRAMRLRSGQLAEAVVRLDDLPRVQAMAFVNSLRGWIDAELRLPQE