Protein Info for GFF6770 in Variovorax sp. SCN45

Annotation: 2-dehydro-3-deoxyphosphogalactonate aldolase (EC 4.1.2.21)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01081: Aldolase
  • amino acids 11 to 189 (179 residues), 120.3 bits, E=3.6e-39

Best Hits

Swiss-Prot: 51% identical to DGOA_RHIME: Probable 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (dgoA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01631, 2-dehydro-3-deoxyphosphogalactonate aldolase [EC: 4.1.2.21] (inferred from 89% identity to vpe:Varpa_4265)

MetaCyc: 47% identical to 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (Escherichia coli K-12 substr. MG1655)
2-dehydro-3-deoxy-6-phosphogalactonate aldolase. [EC: 4.1.2.21, 4.1.2.55]

Predicted SEED Role

"2-dehydro-3-deoxyphosphogalactonate aldolase (EC 4.1.2.21)" in subsystem D-galactonate catabolism (EC 4.1.2.21)

MetaCyc Pathways

• superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
• Entner-Doudoroff pathway I (9/9 steps found)
• D-fructuronate degradation (4/4 steps found)
• Entner-Doudoroff shunt (2/2 steps found)
• superpathway of β-D-glucuronosides degradation (5/7 steps found)
• D-galactonate degradation (2/3 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (3/5 steps found)
• D-galacturonate degradation I (3/5 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
• D-glucosaminate degradation (1/3 steps found)
• superpathway of hexuronide and hexuronate degradation (6/10 steps found)
• L-glucose degradation (3/7 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)

KEGG Metabolic Maps

• Galactose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.21 or 4.1.2.55

Protein Sequence (214 amino acids)

>GFF6770 2-dehydro-3-deoxyphosphogalactonate aldolase (EC 4.1.2.21) (Variovorax sp. SCN45)
MTTTPLEKFNAAMRELPLVAILRGLTPAEAADVGDAIVEPGFRLLEVPLNSPQPLESIAL
MRKRFPQALVGAGTVLAPQQVRDVHAAGGELIVSPNYNADVIAEAARLGMVCLPGVMTPT
EAFGALAAGATGLKLFPAELASPAVVKALLAVLPAGTPVMPVGGITPSNMADWRAGGAAG
FGIGSALYKPGKQAAAVREDARKFIAAWTGAIQA