Protein Info for GFF6741 in Variovorax sp. SCN45

Annotation: UPF0053 inner membrane protein YoaE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 522 transmembrane" amino acids 12 to 37 (26 residues), see Phobius details amino acids 52 to 73 (22 residues), see Phobius details amino acids 77 to 79 (3 residues), see Phobius details amino acids 83 to 101 (19 residues), see Phobius details amino acids 122 to 143 (22 residues), see Phobius details amino acids 155 to 173 (19 residues), see Phobius details amino acids 185 to 204 (20 residues), see Phobius details amino acids 215 to 233 (19 residues), see Phobius details PF03741: TerC" amino acids 16 to 205 (190 residues), 156.7 bits, see alignment E=8e-50 PF00571: CBS" amino acids 374 to 422 (49 residues), 28.6 bits, see alignment 2.3e-10 PF03471: CorC_HlyC" amino acids 437 to 515 (79 residues), 56.6 bits, see alignment E=3.2e-19

Best Hits

KEGG orthology group: None (inferred from 64% identity to bpt:Bpet3456)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (522 amino acids)

>GFF6741 UPF0053 inner membrane protein YoaE (Variovorax sp. SCN45)
MIVELLTDPAAWIGLLTLVVLEIVLGIDNLIFIAILAEKLPPHLRDRARRLGLGLALFMR
LGLLSVVSWLVTLTTPLFTVFGQGFSGRDLILLIGGLFLLFKATSELHERLEGVTHTASG
STAYASFGLVVTQIVVLDAVFSLDAVITAVGMVDHLPVMMAAVIISIGIMLWASKPLTRF
VNAHPTVVVLCLSFLLMIGLSLVAEGLGFHIPKGYLYGAIGFSVMIETLNQWAKRNALKH
EARRPLRDRTAESILRLLGGRGPGEPVPAGATADGEAPLPEPAFAIEERNMVSGVLSLAD
RNVRSVMTPRADISWVDLNDDPDAVREQLLDTPHGIFPVCRGSLDEVVGVARAKDLLGHL
LRHGKIDESGGLRAPIYVPESTTVIRLIDTLRGARGQLALVNDEHGTLTGVVTPIDVLEA
IAGEFPDEDETLEIQQTAADTWTVSGSADLHLLEQALQTHGLLSDDDSYTSVAGFLLACF
GGLPSPGQTWVHDGCEFEVTDVDAQRIRTVIVRRLPATESAN