Protein Info for GFF669 in Methylophilus sp. DMC18

Annotation: Pyrroloquinoline-quinone synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 253 TIGR02111: coenzyme PQQ biosynthesis protein C" amino acids 12 to 236 (225 residues), 339.1 bits, see alignment E=6.5e-106 PF03070: TENA_THI-4" amino acids 18 to 226 (209 residues), 165.7 bits, see alignment E=6.4e-53

Best Hits

Swiss-Prot: 65% identical to PQQC_PSEAE: Pyrroloquinoline-quinone synthase (pqqC) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K06137, pyrroloquinoline-quinone synthase [EC: 1.3.3.11] (inferred from 87% identity to mep:MPQ_1591)

MetaCyc: 60% identical to pyrroloquinoline-quinone synthase monomer (Klebsiella pneumoniae)
Pyrroloquinoline-quinone synthase. [EC: 1.3.3.11]

Predicted SEED Role

"Pyrroloquinoline-quinone synthase (EC 1.3.3.11)" (EC 1.3.3.11)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (253 amino acids)

>GFF669 Pyrroloquinoline-quinone synthase (Methylophilus sp. DMC18)
MNAVSHDNLPWSREEFEAKLREKGQGYHIYHPLHMLMYEGKLSREQLQCWVANRYYYQIM
IPQKDAAIMSNCPDKEVRKGWIHRITDHDGYEGSEGGIEAWVKLGEAVGLTREQVTSLEL
VSPGVRFAVDAYVNFARQRPWQESVCSSLTELFAPHIHQQRISSWPTMYPWVKEEGFIYF
KKRLTEARRDVEQGLDITLDYFSVSRDMQLRALDILQFKLDVLWVIADAIMLASTQVKVE
DRDYTRQPVIKFR