Protein Info for GFF66 in Methylophilus sp. DMC18

Annotation: Beta-barrel assembly-enhancing protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 517 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF01435: Peptidase_M48" amino acids 63 to 241 (179 residues), 122.4 bits, see alignment E=7.2e-39 PF13432: TPR_16" amino acids 279 to 341 (63 residues), 35 bits, see alignment E=5.6e-12 PF13181: TPR_8" amino acids 282 to 306 (25 residues), 13.1 bits, see alignment (E = 3.2e-05) amino acids 314 to 342 (29 residues), 18.1 bits, see alignment (E = 8.4e-07) PF14559: TPR_19" amino acids 320 to 385 (66 residues), 27.1 bits, see alignment E=1.5e-09

Best Hits

KEGG orthology group: None (inferred from 66% identity to mmb:Mmol_0577)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (517 amino acids)

>GFF66 Beta-barrel assembly-enhancing protease (Methylophilus sp. DMC18)
MIKKSILCPLVLSAGLLACGVNPVTKEREFQFVSQDKEIQIGQQNYSPARQSQGGDYTLD
PELTRYVQQVGQRLAAVSDRPDLPYEFVVLNDSVPNAWAMPGGKIAFNRGLLYELHSEAE
LAAVLGHEIVHAAARHGAKGMERGIFMQGAMLAVGLATRDSNYANLVVGGAQLGGQLITS
KYGREAESEADHYGMKYMKLAGYDPAAAVTLQETFVRLSQGKRQDFLSGLFASHPPSQER
VDLNEKTLAELGTGGEMGKEIYAQKVAKLMATREAYKAYDEGKEALQKGDTEKAKTLAKK
AISIEPREARFEELLGDIALTKKNTTEALAFYDKAIQMQPDYFKPYVQSGIALFNAGKKE
QAESFLKKANALLPTAPGYALLGQIAEGRGETALALQHYQLAASSDSEIGKEAAARAMRL
DLPRNPGRYLPAGPLADDTGMVYAAVQNNSNVPVGRVQVRMLQYDSRGRMVNQTRSMLIT
GGIAPGRRGSVATGVRIIDQADLQFFRVVVEGAELAN