Protein Info for GFF6590 in Variovorax sp. SCN45

Annotation: Niacin transporter NiaP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 transmembrane" amino acids 8 to 32 (25 residues), see Phobius details amino acids 45 to 66 (22 residues), see Phobius details amino acids 74 to 93 (20 residues), see Phobius details amino acids 99 to 120 (22 residues), see Phobius details amino acids 132 to 153 (22 residues), see Phobius details amino acids 159 to 177 (19 residues), see Phobius details amino acids 250 to 272 (23 residues), see Phobius details amino acids 284 to 305 (22 residues), see Phobius details amino acids 313 to 332 (20 residues), see Phobius details amino acids 339 to 362 (24 residues), see Phobius details amino acids 375 to 400 (26 residues), see Phobius details amino acids 406 to 426 (21 residues), see Phobius details PF07690: MFS_1" amino acids 15 to 391 (377 residues), 186.2 bits, see alignment E=8.7e-59 amino acids 297 to 428 (132 residues), 39.7 bits, see alignment E=2.9e-14 PF00083: Sugar_tr" amino acids 35 to 436 (402 residues), 151.3 bits, see alignment E=4.3e-48

Best Hits

KEGG orthology group: K08369, MFS transporter, putative metabolite:H+ symporter (inferred from 78% identity to cti:RALTA_B1865)

Predicted SEED Role

"Niacin transporter NiaP" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (438 amino acids)

>GFF6590 Niacin transporter NiaP (Variovorax sp. SCN45)
MTSYQRRLFAIIATAWFFDSMDLGIMTFVLGSIKTEFGLSTMQTGLLASSSFLGMFLGAA
TAGMLADKFGRKPVFQLSMIFWGVGSLMCGLSHSANELMAYRVLLGFGMGMEFPIGLAMV
SEIVPARSRGRYIAILEGFWPIGFIAAGVTAYFLLSIIGWRGIFIALAVPAVFVFVVRRS
IPESPRWLEDAGRHDEADNVMSGFEQKVLRASGMKSLPAVEAGVAPERAIGRGAAFAELW
KGVYGKRTAMLWALWLFALLGYYGLTTWLGAFLQQAGYEVTKSVLYTVYISLAGIPGFIF
SAWLLEKWGRKPTCMLMLVGSAASAYMYGQAAASHAPIAQLISAGLCMQFFMFGMWSVLY
AYTPELYPTRSRATGAGFASSIGRIGSLMGPYIVGLVLPVAGQSGVFSLGAACFVAAAMV
VMLFGIETKGQSLEQLSH