Protein Info for GFF655 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: DNA-binding domain of ModE / Molybdate-binding domain of ModE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 262 TIGR00637: ModE molybdate transport repressor domain" amino acids 16 to 113 (98 residues), 134.6 bits, see alignment E=1.1e-43 TIGR00638: molybdenum-pterin binding domain" amino acids 123 to 192 (70 residues), 86.2 bits, see alignment E=1.1e-28 PF03459: TOBE" amino acids 125 to 187 (63 residues), 44.7 bits, see alignment E=1.2e-15 amino acids 198 to 258 (61 residues), 51.5 bits, see alignment E=9.6e-18

Best Hits

Swiss-Prot: 89% identical to MODE_SHIFL: Transcriptional regulator ModE (modE) from Shigella flexneri

KEGG orthology group: K02019, molybdate transport system regulatory protein (inferred from 99% identity to spt:SPA1973)

Predicted SEED Role

"DNA-binding domain of ModE / Molybdate-binding domain of ModE" in subsystem Molybdenum cofactor biosynthesis or Transport of Molybdenum

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (262 amino acids)

>GFF655 DNA-binding domain of ModE / Molybdate-binding domain of ModE (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINDMNQLSE
HMLVERATGGKGGGGAVLTRYGQRLIQLYDLLGQIQQKAFDVLSDDDALPLDSLLAAISR
FSLQTSARNQWFGTITARDRDLVQQHVDVLLADGKTRLKVALTAQSGERLGLEEGKEVLI
LLKAPWVGITRDAAVARAADNQLSGTISHIERGAEQCEVLMALPDGQTLCATIPTSDAAT
LKEGDDVIAWFNADRVIIATLC