Protein Info for GFF6478 in Variovorax sp. SCN45

Annotation: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 969 PF02347: GDC-P" amino acids 21 to 448 (428 residues), 583.5 bits, see alignment E=2.8e-179 amino acids 465 to 743 (279 residues), 40.4 bits, see alignment E=1.9e-14 TIGR00461: glycine dehydrogenase" amino acids 21 to 957 (937 residues), 1431.1 bits, see alignment E=0 PF21478: GcvP2_C" amino acids 785 to 906 (122 residues), 194.9 bits, see alignment E=3.6e-62

Best Hits

Swiss-Prot: 59% identical to GCSP2_PSEPF: Glycine dehydrogenase (decarboxylating) 2 (gcvP2) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 77% identity to ajs:Ajs_1936)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (969 amino acids)

>GFF6478 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2) (Variovorax sp. SCN45)
MPTPALPSLQELENAEEFLARHIGIDAADEARMLPVIGSETRSELIDGIVPAAIRRARPM
RLPAPVTEADALAELKAMASKNKVFRNFIGQGYYGTHTPGVILRNILENPAWYTAYTPYQ
AEISQGRMEALLNFQTMVCDLTGMAIANASMLDEATAAAEAMTLAKRSVKSKSNVFLVSG
DCHPQTIEVIKTRAAPLGIEVKVSTVSETLPHLMVSGAFFGVLAQYPATTGHVHDLRPLA
GHAHQCDAAFIVAADLLALTLLVAPGEFDADIVCGTTQRFGMPLCNGGPHAAYLACRDEF
KRSLPGRLVGVSVDTHGQPAYRLALQTREQHIRREKATSNICTAQVLPAVVASMYAVYHG
PDGLTRIAQRVAALTAILSAGLSQMGREPVNTTAFDSLTIRTGDDTPAIIERAQAAGVNL
RQRLQQHLGISLDETTTRADVETLWTLFAPVGKALPRFDDLAASAAPLIPEDLRRASAFL
SHPVFNTHKSETAMLRYIRSLSDKDLALDRSMIPLGSCTMKLNATSEMIPITWPEFANIH
PFAPADQQLGYAQLDAQLRAWLCEATGYAGISLQPNAGSQGEYAGLLAIKSFHEAKGQGH
RNICLIPSSAHGTNPASAQMVGLQVVVTACDAQGNVDMDDLKRACEKHSDKLAAVMITYP
STHGVFETRVKELCELVHAHGGRVYVDGANMNALVGVAAPGEFGGDVSHLNLHKTFCIPH
GGGGPGVGPVCVVEDLVPYLPGHATAGVPSHGVGAVSAAPLGNAAVLPISWMYCRMMGAK
GLQAATETAILSANYISARLKDHYPTLYASPNGHVAHECILDLRPLKDTSGVTAEDVAKR
LIDYGFHAPTLSFPVPGTLMVEPTESEPLAELDRFIDAMIAIRGEIRRIEEGVWPKEDNP
LKHAPHTAASLLGTEWSHPYSRELGAYPLATLKNAKYWPPIGRVDNVYGDRNLFCSCVPV
GDYKETEEA