Protein Info for GFF644 in Xanthobacter sp. DMC5

Annotation: Adenine permease AdeP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 transmembrane" amino acids 16 to 37 (22 residues), see Phobius details amino acids 43 to 67 (25 residues), see Phobius details amino acids 75 to 96 (22 residues), see Phobius details amino acids 102 to 120 (19 residues), see Phobius details amino acids 134 to 158 (25 residues), see Phobius details amino acids 164 to 188 (25 residues), see Phobius details amino acids 196 to 220 (25 residues), see Phobius details amino acids 240 to 264 (25 residues), see Phobius details amino acids 284 to 307 (24 residues), see Phobius details amino acids 319 to 341 (23 residues), see Phobius details amino acids 347 to 367 (21 residues), see Phobius details amino acids 376 to 404 (29 residues), see Phobius details amino acids 414 to 431 (18 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 21 to 394 (374 residues), 144.9 bits, see alignment E=1.4e-46

Best Hits

Swiss-Prot: 50% identical to Y326_METJA: Putative permease MJ0326 (MJ0326) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 57% identity to pfv:Psefu_0514)

MetaCyc: 48% identical to adenine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-447

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (432 amino acids)

>GFF644 Adenine permease AdeP (Xanthobacter sp. DMC5)
MRGLIERVFQLEAHGTTILTEVVAGITTFLTMAYIVVVNPQIMAQAGIDAGAAFTATCLS
AAFGSAMMGIIANYPIAVAPAMGINAYFTFTVVLGMGVPWQQALGAVFVSGVLFLALSLF
KVREWLLNSIPMSLKLGMGTGIGLFLALLGLKGMGVVVASPVTLVALGNLAAPPTFIACG
GFLLMSGLAARGVPGAILIGIAAATLAGVPFGLVSFSGIVSAPPSLAPTLLQLDIAGVLR
LSMTGVIAALFLLVLLDNMGTLIATLYKGGLMREDGSVPRLGRVLIADSGGAIVGSALGT
STLTSYIESAAGIEAGGRTGLTAVVVALMFLACLLFAPLALAVPGYATAPALLVVALAMI
GAMGDLPWDDAAEAFPAAATALAVVFTFSIATGIGLGFITYVAVNLIAGRWRRISGAVWV
IAIASAVLLVIE